ArticleThe Journal of general physiology2010
Coordinated control of sensitivity by two splice variants of Gα(o) in retinal ON bipolar cells.
Article in The Journal of general physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 32 citations in OpenAlex.
- Photoreceptor degeneration induces homeostatic rewiring of rod bipolar cells.Current biology : CB · 2025Article
- Efficient in vivo labeling of endogenous proteins with SMART delineates retina cellular and synaptic organization.Nature communications · 2025Article
- Temporal Transformation of the Rod Single-Photon Response in the Retinal Circuitry.Investigative ophthalmology & visual science · 2025Article
- GαJournal of neurochemistry · 2025Article
- Light Adaptation of Retinal Rod Bipolar Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- A Novel Role for UNC119 as an Enhancer of Synaptic Transmission.International journal of molecular sciences · 2023Article
- Retinal TRP channels: Cell-type-specific regulators of retinal homeostasis and multimodal integration.Progress in retinal and eye research · 2023Review
- A hyperpolarizing rod bipolar cell in the sea lamprey, Petromyzon marinus.The Journal of experimental biology · 2022Article
- The Transduction Cascade in Retinal ON-Bipolar Cells: Signal Processing and Disease.Annual review of vision science · 2017Review
- Elevated cAMP improves signal-to-noise ratio in amphibian rod photoreceptors.The Journal of general physiology · 2017Article
- Lack of mGluR6-related cascade elements leads to retrograde trans-synaptic effects on rod photoreceptor synapses via matrix-associated proteins.The European journal of neuroscience · 2016Article
- Biallelic Mutations in GNB3 Cause a Unique Form of Autosomal-Recessive Congenital Stationary Night Blindness.American journal of human genetics · 2016Article
- The TRPM1 channel in ON-bipolar cells is gated by both the α and the βγ subunits of the G-protein Go.Scientific reports · 2016Article
- The Effect of PKCα on the Light Response of Rod Bipolar Cells in the Mouse Retina.Investigative ophthalmology & visual science · 2015Article
- Article
- Differential function of Gγ13 in rod bipolar and ON cone bipolar cells.The Journal of physiology · 2015Article
- A Naturally Occurring Canine Model of Autosomal Recessive Congenital Stationary Night Blindness.PloS one · 2015Article
- ON-OFF Interactions in the Retina: Role of Glycine and GABA.Current neuropharmacology · 2014Article
- Transducin translocation contributes to rod survival and enhances synaptic transmission from rods to rod bipolar cells.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Depolarizing bipolar cell dysfunction due to a Trpm1 point mutation.Journal of neurophysiology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
The high sensitivity of scotopic vision depends on the efficient retinal processing of single photon responses generated by individual rod photoreceptors. At the first synapse in the mammalian retina, rod outputs are pooled by a rod "ON" bipolar cell, which uses a G-protein signaling cascade to enhance the fidelity of the single photon response under conditions where few rods absorb light. Here we show in mouse rod bipolar cells that both splice variants of the G(o) α subunit, Gα(o1) and Gα(o2), mediate light responses under the control of mGluR6 receptors, and their coordinated action is critical for maximizing sensitivity. We found that the light response of rod bipolar cells was primarily mediated by Gα(o1), but the loss of Gα(o2) caused a reduction in the light sensitivity. This reduced sensitivity was not attributable to the reduction in the total number of G(o) α subunits, or the altered balance of expression levels between the two splice variants. These results indicate that Gα(o1) and Gα(o2) both mediate a depolarizing light response in rod bipolar cells without occluding each other's actions, suggesting they might act independently on a common effector. Thus, Gα(o2) plays a role in improving the sensitivity of rod bipolar cells through its action with Gα(o1). The coordinated action of two splice variants of a single Gα may represent a novel mechanism for the fine control of G-protein activity.
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Registered trials
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