ArticleProceedings of the National Academy of Sciences of the United States of America2010
Highly aneuploid zebrafish malignant peripheral nerve sheath tumors have genetic alterations similar to human cancers.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Effects of two chd2-knockout strains on the morphology and behavior in zebrafish.Development genes and evolution · 2024Article
- Microbial elimination of carbamate pesticides: specific strains and promising enzymes.Applied microbiology and biotechnology · 2022Review
- Loss of smarcad1a accelerates tumorigenesis of malignant peripheral nerve sheath tumors in zebrafish.Genes, chromosomes & cancer · 2021Article
- Identification ofOncotarget · 2018Article
- Visualization of Cellular Electrical Activity in Zebrafish Early Embryos and Tumors.Journal of visualized experiments : JoVE · 2018Article
- Development of zebrafish medulloblastoma-like PNET model by TALEN-mediated somatic gene inactivation.Oncotarget · 2017Article
- KANK1 inhibits cell growth by inducing apoptosis through regulating CXXC5 in human malignant peripheral nerve sheath tumors.Scientific reports · 2017Article
- Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Genomic Approaches to Zebrafish Cancer.Advances in experimental medicine and biology · 2016Review
- Cross-species oncogenomics using zebrafish models of cancer.Current opinion in genetics & development · 2015Review
- A GFP-Tagged Gross Deletion on Chromosome 1 Causes Malignant Peripheral Nerve Sheath Tumors and Carcinomas in Zebrafish.PloS one · 2015Article
- Zebrafish as a model to assess cancer heterogeneity, progression and relapse.Disease models & mechanisms · 2014Review
- Phylooncogenomics: Examining the cancer genome in the context of vertebrate evolution.Applied & translational genomics · 2013Review
- Zebrafish cancer: the state of the art and the path forward.Nature reviews. Cancer · 2013Review
- Comparative oncogenomic analysis of copy number alterations in human and zebrafish tumors enables cancer driver discovery.PLoS genetics · 2013Article
- Cross-species array comparative genomic hybridization identifies novel oncogenic events in zebrafish and human embryonal rhabdomyosarcoma.PLoS genetics · 2013Article
- Heterozygous inactivation of tsc2 enhances tumorigenesis in p53 mutant zebrafish.Disease models & mechanisms · 2013Article
- Applications for next-generation sequencing in fish ecotoxicogenomics.Frontiers in genetics · 2012Article
- Genome evolution and meiotic maps by massively parallel DNA sequencing: spotted gar, an outgroup for the teleost genome duplication.Genetics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Aneuploidy is a hallmark of human cancers, but most mouse cancer models lack the extensive aneuploidy seen in many human tumors. The zebrafish is becoming an increasingly popular model for studying cancer. Here we report that malignant peripheral nerve sheath tumors (MPNSTs) that arise in zebrafish as a result of mutations in either ribosomal protein (rp) genes or in p53 are highly aneuploid. Karyotyping reveals that these tumors frequently harbor near-triploid numbers of chromosomes, and they vary in chromosome number from cell to cell within a single tumor. Using array comparative genomic hybridization, we found that, as in human cancers, certain fish chromosomes are preferentially overrepresented, whereas others are underrepresented in many MPNSTs. In addition, we obtained evidence for recurrent subchromosomal amplifications and deletions that may contain genes involved in cancer initiation or progression. These focal amplifications encompassed several genes whose amplification is observed in human tumors, including met, cyclinD2, slc45a3, and cdk6. One focal amplification included fgf6a. Increasing fgf signaling via a mutation that overexpresses fgf8 accelerated the onset of MPNSTs in fish bearing a mutation in p53, suggesting that fgf6a itself may be a driver of MPNSTs. Our results suggest that the zebrafish is a useful model in which to study aneuploidy in human cancer and in which to identify candidate genes that may act as drivers in fish and potentially also in human tumors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.