Evidence map›Paper›PMID 20837397›Full record

ReviewCurrent opinion in microbiology2010

Horizontal gene transfer and the genomics of enterococcal antibiotic resistance.

Kelli L Palmer, Veronica N Kos, Michael S Gilmore

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers.

0numbers the graph read from it
0cells of the map it votes in
159citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

159 citing papers in PubMed, 303 citations in OpenAlex.

  1. Randomized study ofWorld journal of gastroenterology · 2025
    Trial
  2. Investigating pathways of vancomycin-resistantmedRxiv : the preprint server for health sciences · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Impact of stopping contact precautions onAntimicrobial stewardship & healthcare epidemiology : ASHE · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Antibiotic resistome in the glacier forelands of polar regions.Applied and environmental microbiology · 2025
    Article
  15. Review
  16. Article
  17. Antimicrobial Susceptibility Profiles of CommensalAntibiotics (Basel, Switzerland) · 2025
    Article
  18. Article
  19. Article
  20. Article

99 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kelli L PalmerDepartments of Ophthalmology, and Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA, USA.
Veronica N Kos
Michael S Gilmore
Harvard University · US

Funding

Technical Mother Machine CoreP01AI083214 · NIAID · SCHEPENS EYE RESEARCH INSTITUTE · PI Michael S Gilmore · 2009 to 2026
$39.4M
E. faecalis Pathogenicity IslandR01AI072360 · NIAID · SCHEPENS EYE RESEARCH INSTITUTE · PI GILMORE, MICHAEL S · 2007 to 2017
$3.8M
NIAID NIH HHS P01 AI083214NIAID NIH HHS P01AI083214NIAID NIH HHS R01 AI072360
6 · The paper itself

Abstract

Enterococci are Gram-positive bacteria that normally colonize gastrointestinal tracts of humans and animals. They are of growing concern because of their ability to cause antibiotic resistant hospital infections. Antibiotic resistance has been acquired, and has disseminated throughout enterococci, via horizontal transfer of mobile genetic elements. This transmission has been mediated mainly by conjugative plasmids of the pheromone-responsive and broad host range incompatibility group 18 type. Genome sequencing is revealing the extent of diversity of these and other mobile elements in enterococci, as well as the extent of recombination and rearrangement resulting in new phenotypes. Pheromone-responsive plasmids were recently shown to promote genome plasticity in antibiotic resistant Enterococcus faecalis, and their involvement has been implicated in E. faecium as well. Further, incompatibility group 18 plasmids have recently played an important role in mediating transfer of vancomycin resistance from enterococci to methicillin-resistant strains of S. aureus.

Indexed as

Drug Resistance, Multiple, BacterialGene Transfer, HorizontalAnti-Bacterial AgentsEnterococcus faecalisGenome, BacterialMicrobial Sensitivity TestsPheromonesPlasmidsVancomycin ResistanceAnti-Bacterial AgentsPheromones

Identifiers

PMID20837397
PMCPMC2955785
OpenAlexW1988657382

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.