Evidence map›Paper›PMID 20837111›Full record

ReviewFitoterapia2011

Identifying botanical mechanisms of action.

May Fern Toh, Joanna E Burdette

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Fitoterapia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

May Fern TohDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
Joanna E Burdette
University of Illinois Chicago · US

Funding

UIC Program for Interdisciplinary Careers in Women's Health ResearchK12HD055892 · NICHD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GELLER, STACIE E. · 2007 to 2016
$4.9M
EXTRAMURAL RESEARCH FACILITIES CONSTRUCTIONC06RR015482 · NCRR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BAUMAN, JERRY L · 2000 to 2000
$909k
Identification of novel phytoprogestins from hops and red cloverR21AT005377 · NCCIH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BURDETTE, JOANNA E · 2010 to 2011
$430k
Ovulation, inclusion cysts, and p53 mutations in a mouse model of ovarian cancerR03CA139492 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BURDETTE, JOANNA E · 2009 to 2010
$157k
NCCIH NIH HHS R21 AT005377NCI NIH HHS R03 CA139492NCI NIH HHS R03CA139492NCRR NIH HHS C06 RR015482NCRR NIH HHS C06RR15482NICHD NIH HHS K12 HD055892NICHD NIH HHS K12HD055892
6 · The paper itself

Abstract

The biological mechanism of action for any botanical extract is a necessary part of discovery to determine pharmacological use and safety. Interestingly, many activities that are governed by endogenous compounds are not fully understood making the characterization of mechanisms elusive. For example, phytoestrogens are being consumed for menopausal symptoms while the biological action of estradiol are still being investigated. Therefore, long term efficacy and safety issues are a challenge in the field. As new activities are associated with new biological pathways, an important component of therapeutic discovery will need to be the re-evaluation of negative or less active natural products to determine their relative use as medicines.

Indexed as

Drug DiscoveryMenopausePhytoestrogensPhytotherapyEstradiolFemaleHumansPlant ExtractsEstradiolPhytoestrogensPlant Extracts

Identifiers

PMID20837111
PMCPMC3026059
OpenAlexW2046086922

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.