Evidence map›Paper›PMID 20836867›Full record

SynthesisBMC musculoskeletal disorders2010

Adverse effects of extra-articular corticosteroid injections: a systematic review.

Aaltien Brinks, Bart W Koes, Aloysius C W Volkers, Jan A N Verhaar, Sita M A Bierma-Zeinstra

2 registry-linked trialsOpen access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC musculoskeletal disorders, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 88 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 8 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04895956 phase4recruitingnot on this mapstarted 2022, after this paper: background citation

Intra-sheath vs Extra-sheath Injection for De Quervain's Tenosynovitis

TypeinterventionalSponsorUniversity of California, DavisRan2022 to 2026Enrolled80ConditionsDe Quervain TenosynovitisArmsIntra-sheath injection, Extra-sheath injection, Ultrasound
NCT06056765 nacompletednot on this mapstarted 2024, after this paper: background citation

Effect of ESWT Versus Exercise Treatment for Thumb Carpometacarpal Osteoarthritis: a Randomized Trial.

TypeinterventionalSponsorAzienda Ospedaliero-Universitaria Consorziale Policlinico di BariRan2024 to 2025Enrolled72ConditionsThumb Osteoarthritis, Hand InjuriesArms"Minilith", Storz, Swiss
3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 8 syntheses or guidelines pooled it, 231 citations in OpenAlex.

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  3. Non-steroidal anti-inflammatory drugs (NSAIDs) for trigger finger.The Cochrane database of systematic reviews · 2021
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28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Aaltien BrinksDepartment of General Practice Erasmus Medical Center PO Box 2040, 3000 CA, The Netherlands. a.brinks@erasmusmc.nl
Bart W Koes
Aloysius C W Volkers
Jan A N Verhaar
Sita M A Bierma-Zeinstra
Erasmus MC · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo estimate the occurrence and type of adverse effects after application of an extra-articular (soft tissue) corticosteroid injection.

methodsA systematic review of the literature was made based on a PubMed and Embase search covering the period 1956 to January 2010. Case reports were included, as were prospective and retrospective studies that reported adverse events of corticosteroid injection. All clinical trials which used extra-articular corticosteroid injections were examined. We divided the reported adverse events into major (defined as those needing intervention or not disappearing) and minor ones (transient, not requiring intervention).

resultsThe search yielded 87 relevant studies:44 case reports, 37 prospective studies and 6 retrospective studies. The major adverse events included osteomyelitis and protothecosis; one fatal necrotizing fasciitis; cellulitis and ecchymosis; tendon ruptures; atrophy of the plantar fat was described after injecting a neuroma; and local skin effects appeared as atrophy, hypopigmentation or as skin defect. The minor adverse events effects ranged from skin rash to flushing and disturbed menstrual pattern. Increased pain or steroid flare after injection was reported in 19 studies. After extra-articular injection, the incidence of major adverse events ranged from 0-5.8% and that of minor adverse events from 0-81%. It was not feasible to pool the risk for adverse effects due to heterogeneity of study populations and difference in interventions and variance in reporting.

conclusionIn this literature review it was difficult to accurately quantify the incidence of adverse effects after extra-articular corticosteroid injection. The reported adverse events were relatively mild, although one fatal reaction was reported.

Indexed as

Adrenal Cortex HormonesHumansMusculoskeletal DiseasesProspective StudiesRetrospective StudiesAdrenal Cortex Hormones

Identifiers

PMID20836867
PMCPMC2945953
OpenAlexW2159662955

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.