ArticleGenesis (New York, N.Y. : 2000)2010
prdm1a Regulates sox10 and islet1 in the development of neural crest and Rohon-Beard sensory neurons.
Article in Genesis (New York, N.Y. : 2000), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Integrated Transcriptomic and Epigenomic Analysis Reveals Mechanisms Underlying Melanotic Spot Formation in Red Tilapia (International journal of molecular sciences · 2025Article
- Genetic and Developmental Divergence in the Neural Crest Program between Cichlid Fish Species.Molecular biology and evolution · 2024Article
- Genetic and developmental divergence in the neural crest programme between cichlid fish species.bioRxiv : the preprint server for biology · 2024Article
- Human split hand/foot variants are not as functional as wildtype human PRDM1 in the rescue of craniofacial defects.Birth defects research · 2024Article
- Shoc2 controls ERK1/2-driven neural crest development by balancing components of the extracellular matrix.Developmental biology · 2022Article
- The Polycomb group geneFrontiers in neuroscience · 2022Article
- FAM19A5l Affects Mustard Oil-Induced Peripheral Nociception in Zebrafish.Molecular neurobiology · 2021Article
- Article
- Loss of prdm1a accelerates melanoma onset and progression.Molecular carcinogenesis · 2020Article
- Hindbrain and Spinal Cord Contributions to the Cutaneous Sensory Innervation of the Larval Zebrafish Pectoral Fin.Frontiers in neuroanatomy · 2020Article
- Neural crest development: insights from the zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Review
- PRDM1 controls the sequential activation of neural, neural crest and sensory progenitor determinants.Development (Cambridge, England) · 2019Article
- Investigation of Islet2a function in zebrafish embryos: Mutants and morphants differ in morphologic phenotypes and gene expression.PloS one · 2018Article
- Tbx3 represses bmp4 expression and, with Pax6, is required and sufficient for retina formation.Development (Cambridge, England) · 2016Article
- A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation.Science (New York, N.Y.) · 2016Article
- Cdon promotes neural crest migration by regulating N-cadherin localization.Developmental biology · 2015Article
- An emerging role for prdm family genes in dorsoventral patterning of the vertebrate nervous system.Neural development · 2015Review
- Spinal neurons require Islet1 for subtype-specific differentiation of electrical excitability.Neural development · 2014Article
- prdm12b specifies the p1 progenitor domain and reveals a role for V1 interneurons in swim movements.Developmental biology · 2014Article
- Prdm1a directly activates foxd3 and tfap2a during zebrafish neural crest specification.Development (Cambridge, England) · 2013Article
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3 authors.
Funding
Abstract
The PR domain containing 1a, with ZNF domain factor, gene (prdm1a) plays an integral role in the development of a number of different cell types during vertebrate embryogenesis, including neural crest cells, Rohon-Beard (RB) sensory neurons and the cranial neural crest-derived craniofacial skeletal elements. To better understand how Prdm1a regulates the development of various cell types in zebrafish, we performed a microarray analysis comparing wild type and prdm1a mutant embryos and identified a number of genes with altered expression in the absence of prdm1a. Rescue analysis determined that two of these, sox10 and islet1, lie downstream of Prdm1a in the development of neural crest cells and RB neurons, respectively. In addition, we identified a number of other novel downstream targets of Prdm1a that may be important for the development of diverse tissues during zebrafish embryogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.