ReviewProtein science : a publication of the Protein Society2010
New insights into S2P signaling cascades: regulation, variation, and conservation.
Review in Protein science : a publication of the Protein Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 50 citations in OpenAlex.
- Maintaining the Integral Membrane Proteome: Revisiting the Functional Repertoire of Integral Membrane Proteases.Chembiochem : a European journal of chemical biology · 2025Review
- Site-2 protease Sll0528 interacts with RbcR to regulate carbon/nitrogen homeostasis in the cyanobacteriumFrontiers in microbiology · 2025Article
- Article
- Site-2 Protease Slr1821 Regulates Carbon/Nitrogen Homeostasis during Ammonium Stress Acclimation in CyanobacteriumInternational journal of molecular sciences · 2023Article
- The LIV-1 Subfamily of Zinc Transporters: From Origins to Present Day Discoveries.International journal of molecular sciences · 2023Review
- The role of site-2-proteases in bacteria: a review on physiology, virulence, and therapeutic potential.microLife · 2023Review
- Article
- Viruses and Metabolism: The Effects of Viral Infections and Viral Insulins on Host Metabolism.Annual review of virology · 2021Review
- Metallopeptidase Stp1 activates the transcription factor Sre1 in the carotenogenic yeastJournal of lipid research · 2020Article
- Involvement of a Membrane-Bound Amphiphilic Helix in Substrate Discrimination and Binding by anFrontiers in microbiology · 2020Article
- Intramembrane Proteolysis of Astrotactins.The Journal of biological chemistry · 2017Article
- Identification of Specific Variations in a Non-Motile Strain of Cyanobacterium Synechocystis sp. PCC 6803 Originated from ATCC 27184 by Whole Genome Resequencing.International journal of molecular sciences · 2015Article
- Sll0528, a Site-2-Protease, Is Critically Involved in Cold, Salt and Hyperosmotic Stress Acclimation of Cyanobacterium Synechocystis sp. PCC 6803.International journal of molecular sciences · 2014Article
- The HtrA-like protease CD3284 modulates virulence of Clostridium difficile.Infection and immunity · 2014Article
- Site-2 protease responds to oxidative stress and regulates oxidative injury in mammalian cells.Scientific reports · 2014Article
- Site-2 protease substrate specificity and coupling in trans by a PDZ-substrate adapter protein.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The activity of σV, an extracytoplasmic function σ factor of Bacillus subtilis, is controlled by regulated proteolysis of the anti-σ factor RsiV.Journal of bacteriology · 2013Article
- Features of Pro-σK important for cleavage by SpoIVFB, an intramembrane metalloprotease.Journal of bacteriology · 2013Article
- Molecular components of stress-responsive plastid retrograde signaling networks and their involvement in ammonium stress.Plant signaling & behavior · 2013Review
- Genome-wide identification of viral and host transcripts targeted by viral siRNAs in Vitis vinifera.Molecular plant pathology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regulated intramembrane proteolysis (RIP) is a conserved mechanism that regulates signal transduction across the membrane by recruiting membrane-bound proteases to cleave membrane-spanning regulatory proteins. As the first identified protease that performs RIP, the metalloprotease site-2 protease (S2P) has received extensive study during the past decade, and an increasing number of S2P-like proteases have been identified and studied in different organisms; however, some of their substrates and the related S1Ps remain elusive. Here, we review recent research on S2P cascades, including human S2P, E. coli RseP, B. subtilis SpoIVFB and the newly identified S2P homologs. We also discuss the variation and conservation of characterized S2P cascades. The conserved catalytic motif of S2P and prevalence of amino acids of low helical propensity in the transmembrane segments of the substrates suggest a conserved catalytic conformation and mechanism within the S2P family. The review also sheds light on future research on S2P cascades.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.