ReviewWiley interdisciplinary reviews. Systems biology and medicine
Regulation of endothelial cell functions by basement membrane- and arachidonic acid-derived products.
Review in Wiley interdisciplinary reviews. Systems biology and medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Effects of valproic acid on wound healing of the abdominal wall musculoaponeurotic layer: an experimental study in rats.Revista do Colegio Brasileiro de Cirurgioes · 2024Article
- The Roles of Exosomes in Metastasis of Sarcoma: From Biomarkers to Therapeutic Targets.Biomolecules · 2023Review
- The effects of inhibition and siRNA knockdown of collagen-binding integrins on human umbilical vein endothelial cell migration and tube formation.Scientific reports · 2022Article
- Designing Cardiovascular Implants Taking in View the Endothelial Basement Membrane.International journal of molecular sciences · 2021Review
- Epigenetic Regulation of Angiogenesis in Development and Tumors Progression: Potential Implications for Cancer Treatment.Frontiers in cell and developmental biology · 2021Review
- Transmembrane Protein TMEM230, a Target of Glioblastoma Therapy.Frontiers in cellular neuroscience · 2021Article
- Arachidonic acid: Physiological roles and potential health benefits - A review.Journal of advanced research · 2018Review
- A Critical Analysis of the AvailableJournal of ophthalmology · 2017Review
- Heparan Sulfate in the Developing, Healthy, and Injured Lung.American journal of respiratory cell and molecular biology · 2016Review
- Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in amyotrophic lateral sclerosis (ALS).Journal of neural transmission (Vienna, Austria : 1996) · 2014Review
- Techniques and assays for the study of angiogenesis.Experimental biology and medicine (Maywood, N.J.) · 2014Review
- Epoxyeicosatrienoic acids and cardioprotection: the road to translation.Journal of molecular and cellular cardiology · 2014Review
- Blood-brain barrier impairment in MPS III patients.BMC neurology · 2013Article
- The effect of vascular endothelial growth factor in the progression of bladder cancer and diabetic retinopathy.International journal of clinical and experimental medicine · 2013Article
- A proteome comparison between physiological angiogenesis and angiogenesis in glioblastoma.Molecular & cellular proteomics : MCP · 2012Article
- Insulin-like growth factor binding protein-4 differentially inhibits growth factor-induced angiogenesis.The Journal of biological chemistry · 2012Article
- Prostaglandins in cancer cell adhesion, migration, and invasion.International journal of cell biology · 2012Article
- Viscum album exerts anti-inflammatory effect by selectively inhibiting cytokine-induced expression of cyclooxygenase-2.PloS one · 2011Article
- Arachidonic acid randomizes endothelial cell motion and regulates adhesion and migration.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Angiogenesis, the formation of new blood vessels from preexisting vasculature, is required for normal physiological as well as pathological events. The angiogenic process requires endothelial cells to proliferate, migrate, and undergo tubulogenesis. These multistep processes necessitate secretion of pro-angiogenic growth factors, activation of specific intracellular signaling, and interaction of endothelial cells with basement membrane (BM) extracellular matrix components. The generation and release of angiogenic molecules are highly regulated and are influenced by numerous factors, including BM-derived fragments, proteolytic enzymes, as well as metabolites of arachidonic acid (AA). The interactions between these key modulators of angiogenesis is extremely complex, as AA metabolites can regulate the synthesis of soluble angiogenic factors, BM components, as well as enzymes capable of cleaving BM components, which result in the generation of pro- and/or anti-angiogenic products. Furthermore, some BM-derived fragments can alter the expression of AA-converting enzymes and consequently the synthesis of angiogenic factors. In this review we describe the relationship between BM components and AA metabolites with respect to the regulation of endothelial cell functions in health and disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.