Trial reportClinical research in cardiology : official journal of the German Cardiac Society2011
Acute and chronic effects of exercise on inflammatory markers and B-type natriuretic peptide in patients with coronary artery disease.
Trial report in Clinical research in cardiology : official journal of the German Cardiac Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- The effects of exercise training on circulating adhesion molecules in adults: A systematic review and meta-analysis.PloS one · 2023Pooled it
- The effect of placebo adherence on reducing cardiovascular mortality: a meta-analysis.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Pooled it
- The Effects of High- and Moderate-Intensity Exercise on Epithelial Integrity Markers and Inflammatory Responses in Healthy Young Men.European journal of sport science · 2026Trial
- Acute Exercise Challenge and Airway Dynamics in Youth With Sickle Cell Anemia: A Multicenter Study.American journal of hematology · 2026Trial
- Acute effects of post-absorptive and postprandial moderate exercise on markers of inflammation in hyperglycemic individuals.European journal of applied physiology · 2017Trial
- Effects of Acute Endurance Exercise on Plasma Protein Profiles of Endurance-Trained and Untrained Individuals over Time.Mediators of inflammation · 2016Trial
- Heart failure is the most negative consequence of CABG surgery (importance of exercise rehabilitation approach).ARYA atherosclerosis · 2025Review
- A Sedentary Lifestyle Changes the Composition and Predicted Functions of the Gut Bacterial and Fungal Microbiota of Subjects from the Same Company.Current microbiology · 2023Article
- Is moderate-intensity interval training more tolerable than high-intensity interval training in adults with obesity?Biology of sport · 2023Article
- The impacts of exercise interventions on inflammaging markers in overweight/obesity patients with heart failure: A systematic review and meta-analysis of randomized controlled trials.International journal of cardiology. Heart & vasculature · 2023Review
- Review
- Effects of Catheterization on Artery Function and Health: When Should Patients Start Exercising Following Their Coronary Intervention?Sports medicine (Auckland, N.Z.) · 2019Review
- Balancing exercise risk and benefits: lessons learned from sickle cell trait and sickle cell anemia.Hematology. American Society of Hematology. Education Program · 2018Review
- The acute phase inflammatory response to maximal exercise testing in children and young adults with sickle cell anaemia.British journal of haematology · 2015Article
- Gut Microbiome: What We Do and Don't Know.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2015Review
- Association between muscular strength and inflammatory markers among elderly persons with cardiac disease: results from the KORA-Age study.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Article
- Impaired Circulating Angiogenic Cells Mobilization and Metalloproteinase-9 Activity after Dynamic Exercise in Early Metabolic Syndrome.BioMed research international · 2015Article
- Exercise and the microbiota.Gut microbes · 2015Article
- Acute and chronic effects of exercise on circulating endothelial progenitor cells in healthy and diseased patients.Clinical research in cardiology : official journal of the German Cardiac Society · 2013Review
- Inflammation, diabetes, and chronic kidney disease: role of aerobic capacity.Experimental diabetes research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFew studies have prospectively addressed the effects of exercise in the inflammatory activity of patients with coronary artery disease (CAD). We sought to evaluate the consequences of an acute bout of exercise on inflammatory markers and BNP in untrained CAD patients before and after randomization to a training program.
methods34 CAD patients underwent a 50-min acute exercise session on a cycle-ergometer at 65% peak oxygen uptake before and after blood sampling. They were then randomized to a 4-month chronic exercise program (15 patients) or general lifestyle recommendations (19 patients), undergoing a new acute session of exercise after that.
resultsIn the overall population, acute exercise caused a significant increase in C-reactive protein [CRP; 1.79 (4.49) vs. 1.94 (4.89) mg/L, P < 0.001], monokine induced by interferon-γ [Mig; 351 (324) vs. 373 (330) pg/mL, P = 0.027] and vascular adhesion molecule-1 [VCAM-1; 226 (82) vs. 252 (110) pg/mL, P = 0.02]. After 4-months, in exercise-trained patients, there was a significant decrease in the inflammatory response provoked by the acute exercise compared to patients in the control group reflected by a significant decrease in the differences between rest and post-exercise levels of CRP [-0.29 (0.84) mg/L vs. -0.11 (0.21) mg/L, P = 0.05]. Resting BNP was also significantly lower in exercise-trained patients when compared to untrained controls [15.6 (16.2) vs. 9.7 (11.4) pg/mL, P = 0.04 and 19.2 (27.8) vs. 23.2 (27.5) pg/mL, P = 0.76; respectively].
conclusionsChronic exercise training might partially reverse the inflammatory response caused by acute exercise in CAD patients. These results suggest that regular exercise is an important nonpharmacological strategy to the improvement in inflammation in CAD patients.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.