ArticleJournal of cardiovascular translational research2010
Hematologic effects of continuous flow left ventricular assist devices.
Article in Journal of cardiovascular translational research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 111 citations in OpenAlex.
- Decreased Platelet Specific Receptor Expression of P-Selectin and GPIIb/IIIa Predict Future Non-Surgical Bleeding in Patients after Left Ventricular Assist Device Implantation.International journal of molecular sciences · 2022Article
- Medical and Surgical Management of Left Ventricular Assist Device-Associated Intracranial Hemorrhage.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2021Article
- The Use of Factor Eight Inhibitor Bypass Activity (FEIBA) for the Treatment of Perioperative Hemorrhage in Left Ventricular Assist Device Implantation.Journal of cardiothoracic and vascular anesthesia · 2021Article
- Role of imaging in diagnosis and management of left ventricular assist device complications.The international journal of cardiovascular imaging · 2019Review
- Protected percutaneous coronary intervention with Impella CP in a patient with left main disease, severe left ventricular systolic dysfunction and established hemolysis.Cardiovascular diagnosis and therapy · 2019Article
- Acquired von Willebrand Syndrome Associated with Cardiovascular Diseases.Journal of atherosclerosis and thrombosis · 2019Review
- Gastrointestinal Hemorrhage in Left Ventricular Assist Device Patients: Red Scare or Pressure from the Right?Digestive diseases and sciences · 2018Article
- Utility and correlation of known anticoagulation parameters in the management of pediatric ventricular assist devices.World journal of cardiology · 2017Article
- Angiodysplasia in von Willebrand Disease: Understanding the Clinical and Basic Science.Seminars in thrombosis and hemostasis · 2017Review
- Bleeding with the artificial heart: Gastrointestinal hemorrhage in CF-LVAD patients.World journal of gastroenterology · 2017Review
- Gastrointestinal Bleeding During the Index Hospitalization for Mechanical Circulatory Support Devices Implantation, a Nationwide Perspective.Digestive diseases and sciences · 2017Article
- Perioperative onset of acquired von Willebrand syndrome: Comparison between HVAD, HeartMate II and on-pump coronary bypass surgery.PloS one · 2017Article
- Effects of HeartWare ventricular assist device on the von Willebrand factor: results of an academic Belgian center.BMC cardiovascular disorders · 2016Article
- Visualization and analysis of biomaterial-centered thrombus formation within a defined crevice under flow.Biomaterials · 2016Article
- Hemorrhoids screening and treatment prior to LVAD: is it a necessity?Journal of cardiothoracic surgery · 2016Article
- Haemolysis as a first sign of thromboembolic event and acute pump thrombosis in patients with the continuous-flow left ventricular assist device HeartMate II.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2016Article
- Coagulopathy in Mechanical Circulatory Support: A Fine Balance.Current cardiology reports · 2015Review
- Anticoagulation management in mechanical circulatory support.Journal of thoracic disease · 2015Review
- The Incidence, Predictors and Outcomes of Gastrointestinal Bleeding in Patients with Left Ventricular Assist Device (LVAD).Digestive diseases and sciences · 2015Article
- Covering implantable left ventricular assist device (DuraHeart) with free flap.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2015Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The extent of hematologic effects of the new continuous flow left ventricular assist devices (CF-LVAD) has not been studied. Recent clinical studies have demonstrated that hemolysis and thrombosis are not common during CF-LVAD support, however, the incidence of bleeding remains a concern. The rate of postoperative bleeding is similar to that of the prior generation pulsatile LVAD, but gastrointestinal bleeding due to angiodysplasia and arteriovenous malformations is more common and appears to be related to the blood flow rheology of these devices. New evidence suggests that acquired von Willebrand's disease develops in some patients due to the reduction in high molecular weight (HMW) multimers of von Willebrand's factor (vWF). Similar to acquired von Willebrand's disease seen in patients with aortic stenosis, the shear stress of the CF-LVAD may cause proteolysis of the HMW multimers of vWF. In addition to acquired von Willebrand's disease, there is activation of the fibrinolytic system and a loss of platelet numbers and function during CF-LVAD support. The hematologic responses during CF-LVAD support are constantly changing, and antiplatelet therapy may need to be adjusted accordingly. Considerable research is needed to better define the complex hematologic effects during CF-LVAD support. Screening of patients for angiodysplasia and von Willebrand's disease before CF-LVAD implant may allow for effective preemptive treatment. Because bleeding causes significant morbidity for this population, more effective treatment strategies need to be developed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.