Evidence map›Paper›PMID 20835400›Full record

ArticleClinical lipidology2010

Lipoproteins and lipoprotein metabolism in periodontal disease.

Rachel Griffiths, Suzanne Barbour

Open access · greenAbstract read
In one paragraph

Article in Clinical lipidology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. [Association between chronic periodontitis and hyperlipidemia: a Meta-analysis based on observational studies].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2017
    Pooled it
  2. Article
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  5. Review
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  7. Article
  8. Oral health and atherosclerotic cardiovascular disease: A review.American journal of preventive cardiology · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rachel GriffithsDepartment of Biochemistry & Molecular Biology, Virginia Commonwealth University School of Medicine, Box 980614, Richmond, VA 23298-0614, USA.
Suzanne Barbour
Virginia Commonwealth University · US

Funding

PAF ACETYL-HYDROLASE IN LOCALIZED JUVENILE PERIODONTITISP01DE013102 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI SCHENKEIN, HARVEY ALLEN · 2002 to 2004
$4.7M
PAF ACETYL-HYDROLASE IN LOCALIZED JUVENILE PERIODONTITISU19DE013102 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI SCHENKEIN, HARVEY ALLEN · 2000 to 2001
$1.9M
Monocyte Modulation in LAgPR21DE015980 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI BARBOUR, SUZANNE E · 2004 to 2005
$413k
NIDCR NIH HHS P01 DE013102NIDCR NIH HHS R21 DE015980NIDCR NIH HHS U19 DE013102
6 · The paper itself

Abstract

A growing body of evidence indicates that the incidence of atherosclerosis is increased in subjects with periodontitis - a chronic infection of the oral cavity. This article summarizes the evidence that suggests periodontitis shifts the lipoprotein profile to be more proatherogenic. LDL-C is elevated in periodontitis and most studies indicate that triglyceride levels are also increased. By contrast, antiatherogenic HDL tends to be low in periodontitis. Periodontal therapy tends to shift lipoprotein levels to a healthier profile and also reduces subclinical indices of atherosclerosis. In summary, periodontal disease alters lipoprotein metabolism in ways that could promote atherosclerosis and cardiovascular disease.

Identifiers

PMID20835400
PMCPMC2933935
OpenAlexW2080831554

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.