ArticleKorean diabetes journal2010
Clinical Characteristics of Type 2 Diabetes Patients according to Family History of Diabetes.
Article in Korean diabetes journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 26 citations in OpenAlex.
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- Orientin Improves Substrate Utilization and the Expression of Major Genes Involved in Insulin Signaling and Energy Regulation in Cultured Insulin-Resistant Liver Cells.Molecules (Basel, Switzerland) · 2021Article
- Impact of triglycerides and waist circumference on insulin resistance and β-cell function in non-diabetic first-degree relatives of type 2 diabetes.BMC endocrine disorders · 2021Article
- Shared (epi)genomic background connecting neurodegenerative diseases and type 2 diabetes.World journal of diabetes · 2020Review
- Family history of diabetes in both parents is strongly associated with impaired residual β-cell function in Japanese type 2 diabetes patients.Journal of diabetes investigation · 2020Article
- The relationship between age of onset and risk factors including family history and life style in Korean population with type 2 diabetes mellitus.Journal of physical therapy science · 2018Article
- Clinical Characteristics of Subjects with Sulfonylurea-Dependent Type 2 Diabetes.Endocrinology and metabolism (Seoul, Korea) · 2015Article
- The potential impact of family history of metabolic syndrome and risk of type 2 diabetes mellitus: In a highly endogamous population.Indian journal of endocrinology and metabolism · 2014Article
- General and gender characteristics of type 2 diabetes mellitus among the younger and older age groups.Oman medical journal · 2012Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundType 2 diabetes mellitus (T2DM) has a strong genetic component, and its prevalence is notably increased in the family members of T2DM patients. However, there are few studies about the family history of T2DM. We carried out this study to assess the influences of family history on clinical characteristics in T2DM patients.
methodsThis is a cross-sectional study involving 651 T2DM patients. Patient history and physical examination were performed and fasting blood was taken. If any first degree relative was diabetic, a family history of diabetes was considered to exist.
resultsAmong the total 621 patients, 38.4% had a family history of diabetes. Patients with a family history had a younger age, higher weight, younger age at diagnosis and higher triglyceride level than did those without a family history. Dyslipidemia medication and metabolic syndrome were more prevalent in familial diabetes. Sex, blood pressure, previous treatment for diabetes, HbA1c, C-peptide, total cholesterol, high density lipoprotein cholesterol, and low density lipoprotein cholesterol were not different between familial and non-familial diabetes. Upon multiple linear regression analysis, the family history of diabetes remained significantly associated with serum triglyceride level.
conclusionIn T2DM patients with a family history of diabetes, the disease tended to develop earlier. Metabolic syndrome and cardiovascular risk factors are more prevalent in familial T2DM than they were in non-familial T2DM. These results support the necessity of earlier screening for diabetes in family members of T2DM patients and more active prevention against cardiovascular disease in T2DM patients with a family history.
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