ArticleThe EMBO journal2010
Differences in signalling by directly and indirectly binding ligands in bacterial chemotaxis.
Article in The EMBO journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed.
- Parabolic-elliptic and indirect-direct simplifications in chemotaxis systems driven by indirect signalling.Calculus of variations and partial differential equations · 2026Article
- Response ofMicrobiology spectrum · 2025Article
- Role of a single MCP in evolutionary adaptation ofApplied and environmental microbiology · 2025Article
- Thermal shift assay to identify ligands for bacterial sensor proteins.FEMS microbiology reviews · 2025Review
- Signal integration and adaptive sensory diversity tuning in Escherichia coli chemotaxis.Cell systems · 2024Article
- Article
- Direct measurement of dynamic attractant gradients reveals breakdown of the Patlak-Keller-Segel chemotaxis model.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Direct measurement of dynamic attractant gradients reveals breakdown of the Patlak-Keller-Segel chemotaxis model.bioRxiv : the preprint server for biology · 2023Article
- Discovery of a New Chemoeffector forACS bio & med chem Au · 2022Article
- The ecological roles of bacterial chemotaxis.Nature reviews. Microbiology · 2022Review
- Bacterial chemotaxis to saccharides is governed by a trade-off between sensing and uptake.Biophysical journal · 2022Article
- Grounding cognition: heterarchical control mechanisms in biology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- The role of solute binding proteins in signal transduction.Computational and structural biotechnology journal · 2021Review
- Escape band inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- Chemotaxis of Escherichia coli to major hormones and polyamines present in human gut.The ISME journal · 2018Article
- Mechanism of bidirectional thermotaxis ineLife · 2017Article
- Activity, Abundance, and Localization of Quorum Sensing Receptors inFrontiers in microbiology · 2017Article
- Functional Characteristics of the Flying Squirrel's Cecal Microbiota under a Leaf-Based Diet, Based on Multiple Meta-Omic Profiling.Frontiers in microbiology · 2017Article
- Chemotaxis towards autoinducer 2 mediates autoaggregation in Escherichia coli.Nature communications · 2016Article
Corrections and comments
- Commented on by
Authors and funding
4 authors.
Funding
Abstract
In chemotaxis of Escherichia coli and other bacteria, extracellular stimuli are perceived by transmembrane receptors that bind their ligands either directly, or indirectly through periplasmic-binding proteins (BPs). As BPs are also involved in ligand uptake, they provide a link between chemotaxis and nutrient utilization by cells. However, signalling by indirectly binding ligands remains much less understood than signalling by directly binding ligands. Here, we compared intracellular responses mediated by both types of ligands and developed a new mathematical model for signalling by indirectly binding ligands. We show that indirect binding allows cells to better control sensitivity to specific ligands in response to their nutrient environment and to coordinate chemotaxis with ligand transport, but at the cost of the dynamic range being much narrower than for directly binding ligands. We further demonstrate that signal integration by the chemosensory complexes does not depend on the type of ligand. Overall, our data suggest that the distinction between signalling by directly and indirectly binding ligands is more physiologically important than the traditional distinction between high- and low-abundance receptors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.