Trial reportPsychosomatics
Prophylactic antidepressant treatment in patients with hepatitis C on antiviral therapy: a double-blind, placebo-controlled trial.
Trial report in Psychosomatics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Evidence-based interventions to enhance assessment, treatment, and adherence in the chronic Hepatitis C care continuum.The International journal on drug policy · 2015Pooled it
- Antidepressant prophylaxis reduces depression risk but does not improve sustained virological response in hepatitis C interferon recipients without depression at baseline: a systematic review and meta-analysis.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2013Pooled it
- Pooled it
- Citalopram versus other anti-depressive agents for depression.The Cochrane database of systematic reviews · 2012Pooled it
- Neurobehavioral effects of interferon-α in patients with hepatitis-C: symptom dimensions and responsiveness to paroxetine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Trial
- Developing a modified directly observed therapy intervention for hepatitis C treatment in a methadone maintenance program: implications for program replication.The American journal of drug and alcohol abuse · 2012Trial
- Article
- Double blind, randomised trial to compare efficacy of escitalopram versus citalopram for interferon induced depression in hepatitis C patients.Contemporary clinical trials communications · 2020Article
- New direct-acting antivirals for hepatitis C treatment and neuropsychiatric symptoms in psychiatric risk groups.European journal of hospital pharmacy : science and practice · 2019Article
- Multimethod assessment of baseline depression and relationship to hepatitis C treatment discontinuation.International journal of psychiatry in medicine · 2018Article
- Paeoniflorin ameliorates interferon-alpha-induced neuroinflammation and depressive-like behaviors in mice.Oncotarget · 2017Article
- Nutrition, psychoneuroimmunology and depression: the therapeutic implications of omega-3 fatty acids in interferon-α-induced depression.BioMedicine · 2015Article
- Psychiatric and substance use disorders co-morbidities and hepatitis C: Diagnostic and treatment implications.World journal of hepatology · 2015Review
- A longitudinal study evaluating the effects of interferon-alpha therapy on cognitive and psychiatric function in adults with chronic hepatitis C.Journal of psychosomatic research · 2015Article
- Does prophylactic antidepressant treatment boost interferon-alpha treatment completion in HCV?World journal of virology · 2013Review
- Psychiatric treatment considerations with direct acting antivirals in hepatitis C.BMC gastroenterology · 2013Review
- Management algorithm for genotype 1 hepatitis C virus.F1000prime reports · 2013Article
- Depressogenic effects of medications: a review.Dialogues in clinical neuroscience · 2011Review
- Serum Serotonin Levels are Associated with Antiviral Therapy Outcomes in Patients with Chronic Hepatitis C.The open infectious diseases journal · 2010Article
- Depression and suicide ideation in chronic hepatitis C patients untreated and treated with interferon: prevalence, prevention, and treatment.Annals of gastroenterologyReview
Corrections and comments
- Commented on by
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundApproximately one-third of patients undergoing interferon-α (IFN-α) therapy for treatment of the hepatitis C virus (HCV) develop major depression, which decreases functioning and may lead to the reduction or discontinuation of treatment.
objectiveThe authors examined the efficacy of citalopram in preventing IFN-α-induced depression in HCV patients.
methodThis was a randomized, controlled trial comparing citalopram with placebo in 39 HCV patients.
resultsThe rate of IFN-α-induced depression in the sample was 15.4% (6/39). Randomization to citalopram did not decrease the statistical likelihood of developing IFN-α-induced depression (10.5% for citalopram vs. 20.0% for placebo).
conclusionCitalopram does not prevent depression onset; however, an empirically-supported treatment recommendation for IFN-α-induced depression includes monitoring depressive symptoms throughout antiviral therapy and initiating psychiatric treatment at the initial signs of depression.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.