ArticleJournal of bacteriology2010
Role of cross talk in regulating the dynamic expression of the flagellar Salmonella pathogenicity island 1 and type 1 fimbrial genes.
Article in Journal of bacteriology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed.
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- TLR priming licenses NAIP inflammasome activation by immunoevasive ligands.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- ThebioRxiv : the preprint server for biology · 2024Article
- Subversion of a family of antimicrobial proteins byFrontiers in cellular and infection microbiology · 2024Article
- Characterizing the Pathogenic Potential of Crohn's Disease-Associated Adherent-InvasiveEcoSal Plus · 2023Review
- Salmonella adhesion is decreased by hypoxia due to adhesion and motility structure crosstalk.Veterinary research · 2023Article
- Analysis ofFrontiers in cellular and infection microbiology · 2023Review
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- Identifying Bacterial Lineages in Salmonella by Flow Cytometry.EcoSal Plus · 2022Review
- Effect of Environmental Temperatures on Proteome Composition of Salmonella enterica Serovar Typhimurium.Molecular & cellular proteomics : MCP · 2022Article
- Article
- The Nutrient and Energy Pathway Requirements for Surface Motility of Nonpathogenic and UropathogenicJournal of bacteriology · 2021Article
- Single Cell Analysis of Bistable Expression of Pathogenicity Island 1 and the Flagellar Regulon inMicroorganisms · 2021Article
- Regulatory protein HilD stimulates Salmonella Typhimurium invasiveness by promoting smooth swimming via the methyl-accepting chemotaxis protein McpC.Nature communications · 2021Article
- Experimental Evolution of Anticipatory Regulation inFrontiers in microbiology · 2021Article
- Pre-Growth Culture Conditions Affect Type 1 Fimbriae-Dependent Adhesion ofInternational journal of molecular sciences · 2020Article
- Article
- The Small RNA PinT Contributes to PhoP-Mediated Regulation of theJournal of bacteriology · 2019Article
- Synergistic action of SPI-1 gene expression in Salmonella enterica serovar typhimurium through transcriptional crosstalk with the flagellar system.BMC microbiology · 2019Article
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4 authors.
Funding
Abstract
Salmonella enterica, a common food-borne pathogen, differentially regulates the expression of multiple genes during the infection cycle. These genes encode systems related to motility, adhesion, invasion, and intestinal persistence. Key among them is a type three secretion system (T3SS) encoded within Salmonella pathogenicity island 1 (SPI1). In addition to the SPI1 T3SS, other systems, including flagella and type 1 fimbriae, have been implicated in Salmonella pathogenesis. In this study, we investigated the dynamic expression of the flagellar, SPI1, and type 1 fimbrial genes. We demonstrate that these genes are expressed in a temporal hierarchy, beginning with the flagellar genes, followed by the SPI1 genes, and ending with the type 1 fimbrial genes. This hierarchy could mirror the roles of these three systems during the infection cycle. As multiple studies have shown that extensive regulatory cross talk exists between these three systems, we also tested how removing different regulatory links between them affects gene expression dynamics. These results indicate that cross talk is critical for regulating gene expression during transitional phases in the gene expression hierarchy. In addition, we identified a novel regulatory link between flagellar and type 1 fimbrial gene expression dynamics, where we found that the flagellar regulator, FliZ, represses type 1 fimbrial gene expression through the posttranscriptional regulation of FimZ. The significance of these results is that they provide the first systematic study of the effect of regulatory cross talk on the expression dynamics of flagellar, SPI1, and type 1 fimbrial genes.
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