Evidence map›Paper›PMID 20833696›Full record

ReviewSchizophrenia bulletin2010

Developmental vitamin D deficiency and risk of schizophrenia: a 10-year update.

John J McGrath, Thomas H Burne, François Féron, Allan Mackay-Sim, Darryl W Eyles

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Schizophrenia bulletin, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 7 pooled it
12.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 7 syntheses or guidelines pooled it, 229 citations in OpenAlex.

  1. Pooled it
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  6. Country of birth and hospital treatment for psychosis in New South Wales.Social psychiatry and psychiatric epidemiology · 2013
    Pooled it
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  8. Trial
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  10. Review
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  16. Developmental Manipulation-Induced Changes in Cognitive Functioning.Current topics in behavioral neurosciences · 2023
    Article
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  18. Article
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  20. Review

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

John J McGrathQueensland Center for Mental Health Research, The Park Center for Mental Health, Wacol, Queensland 4076, Australia. john_mcgrath@qcmhr.uq.edu.au
Thomas H Burne
François Féron
Allan Mackay-Sim
Darryl W Eyles
University of Queensland · AUCentre National de la Recherche Scientifique · FRGriffith University · AUQueensland Centre for Mental Health Research · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is an urgent need to generate and test candidate risk factors that may explain gradients in the incidence of schizophrenia. Based on clues from epidemiology, we proposed that developmental vitamin D deficiency may contribute to the risk of developing schizophrenia. This hypothesis may explain diverse epidemiological findings including season of birth, the latitude gradients in incidence and prevalence, the increased risk in dark-skinned migrants to certain countries, and the urban-rural gradient. Animal experiments demonstrate that transient prenatal hypovitaminosis D is associated with persisting changes in brain structure and function, including convergent evidence of altered dopaminergic function. A recent case-control study based on neonatal blood samples identified a significant association between neonatal vitamin D status and risk of schizophrenia. This article provides a concise summary of the epidemiological and animal experimental research that has explored this hypothesis.

Indexed as

EnvironmentAnimalsAustraliaBrainDisease Models, AnimalFemaleGeographyHumansPregnancyPrenatal Exposure Delayed EffectsPrevalenceRisk FactorsRural PopulationSchizophreniaSeasonsUrban PopulationVitamin D

Identifiers

PMID20833696
PMCPMC2963051
OpenAlexW2152251767

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.