ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2010
Human bocavirus in children: mono-detection, high viral load and viraemia are associated with respiratory tract infection.
Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 1 of them a synthesis that pooled it.
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Who cites it
79 citing papers in PubMed, 1 synthesis or guideline pooled it, 153 citations in OpenAlex.
- Systematic review on the association between respiratory virus real-time PCR cycle threshold values and clinical presentation or outcomes.The Journal of antimicrobial chemotherapy · 2021Pooled it
- Human bocavirus in the nasopharynx of otitis-prone children.International journal of pediatric otorhinolaryngology · 2012Trial
- Differential Interactions of Tissue-Restricted Host Proteins SPLUNC1 and VAMP8 with VP3 of Human Bocaviruses 1 and 2.Pathogens (Basel, Switzerland) · 2026Article
- Twenty years of human bocavirus research: from an unculturable virus of unclear pathogenicity to a culturable human pathogen and gene therapy vector candidate.Clinical microbiology reviews · 2025Review
- Clinical characteristics and risk factors of severe bocavirus-positive pneumonia in children and a literature review.Pediatric discovery · 2025Article
- Article
- Exploring evidence from cells to clinics: is human bocavirus a gastrointestinal pathogen or just a risk factor?Archives of virology · 2025Review
- Advances in the Relationship between Respiratory Viruses and Asthma.Journal of clinical medicine · 2023Review
- The Burden of Human Bocavirus 1 in Hospitalized Children With Respiratory Tract Infections.Journal of the Pediatric Infectious Diseases Society · 2023Article
- Comparison of MT-PCR with Quantitative PCR for Human Bocavirus in Respiratory Samples with Multiple Respiratory Viruses Detection.Diagnostics (Basel, Switzerland) · 2023Article
- Case Report: Bocavirus Infection Radiologically Resembling a Congestive Heart Failure in a Patient with Metastatic Castration-Resistant Prostate Cancer.F1000Research · 2022Article
- Respiratory tract infection of fatal severe human bocavirus 1 in a 13-month-old child: A case report and literature review.Frontiers in pediatrics · 2022Article
- Role of Human Bocavirus Respiratory Tract Infection in Hematopoietic Cell Transplant Recipients.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Viral and Atypical Bacterial Detection in Young Nepalese Children Hospitalized with Severe Pneumonia.Microbiology spectrum · 2021Article
- Hairpin Transfer-Independent Parvovirus DNA Replication Produces Infectious Virus.Journal of virology · 2021Article
- Prevalence and Molecular Characterization of Human Bocavirus Detected in Croatian Children with Respiratory Infection.Viruses · 2021Article
- Viral Respiratory Pathogens and Lung Injury.Clinical microbiology reviews · 2021Review
- Believing bocavirus: A rare cause of life-threatening acute respiratory distress syndrome requiring extracorporeal membrane oxygenation.Journal of paediatrics and child health · 2020Article
- Human Bocavirus 1 Infection of Well-Differentiated Human Airway Epithelium.Current protocols in microbiology · 2020Article
- Human Bocavirus infection and respiratory tract disease identified in a UK patient cohort.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2020Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesHuman bocavirus 1 (HBoV1) has recently been detected in children with respiratory tract infections (RTI). In order to study whether HBoV1 can cause RTI, we investigated its presence in children with upper RTI (URTI), lower RTI (LRTI) and a control group of children without RTI. STUDY
designNasopharyngeal aspirates (NPA) and blood samples were collected from children admitted to hospital with RTI from 6 June 2007 to 28 February 2009 (n=1154), and from children admitted for elective surgery who had no RTI (n=162). Using polymerase chain reaction (PCR), the NPAs were examined for 17 infectious agents including HBoV1. Blood samples were tested with HBoV1-PCR only.
resultsHBoV1 was detected in NPAs from 10% of patients and 17% of controls. Adjusted for age, gender and the presence of other viruses, HBoV1 was not associated with RTI. In the HBoV1-positive NPAs, at least one other virus was detected in 75% and the virus appeared alone in 25%. Adjusted for age and gender, the detection of HBoV1 as the sole virus was associated with RTI, but not with LRTI. Viraemia was found only in children with RTI. The study showed that it was associated with RTI and LRTI. A high HBoV1-load was associated with LRTI, but not with RTI. No interactions between HBoV1 and other infectious agents were found.
conclusionsOur data support the hypothesis that HBoV1 causes RTI in children, because detection of HBoV1 alone, viraemia and high viral load are associated with RTI and/or LRTI in this age group. However, HBoV1 is common in healthy children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.