ReviewExperimental gerontology
HPA axis responsiveness to stress: implications for healthy aging.
Review in Experimental gerontology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
104 citing papers in PubMed, 4 syntheses or guidelines pooled it, 245 citations in OpenAlex.
- Individual-Level Interventions for Decreasing Job-Related Stress and Enhancing Coping Strategies Among Nurses: A Systematic Review.Frontiers in psychology · 2021Pooled it
- Work-Related Stress, Physio-Pathological Mechanisms, and the Influence of Environmental Genetic Factors.International journal of environmental research and public health · 2019Pooled it
- The association between adversity and hair cortisol levels in humans: A meta-analysis.Psychoneuroendocrinology · 2019Pooled it
- In Obesity, HPA Axis Activity Does Not Increase with BMI, but Declines with Aging: A Meta-Analysis of Clinical Studies.PloS one · 2016Pooled it
- The effects of physical activity on mental health in adolescents with attention-deficit hyperactivity disorder: a randomized controlled trial.The international journal of behavioral nutrition and physical activity · 2025Trial
- High Cardiorespiratory Fitness Is Negatively Associated with Daily Cortisol Output in Healthy Aging Men.PloS one · 2015Trial
- Translational studies in older men using testosterone to treat sarcopenia.Transactions of the American Clinical and Climatological Association · 2014Trial
- Oxytocin as regulator of stress and inflammation in aging.Neuroscience and biobehavioral reviews · 2026Review
- Moderate-to-Vigorous Physical Activity and Suicidal Ideation in Adolescents with Attention Deficit/Hyperactivity Disorder: the Mediating Effects of Mental Health.Journal of autism and developmental disorders · 2026Article
- Article
- Targeting miR-124-3p to Induce Antidepressant-Like Effects in Female Mice: MicroRNA Modulation of Stress Resilience.The European journal of neuroscience · 2026Article
- Aging Leads to Altered Physiological Reactivity in Response to Repeated Social Separation Stress in a Nonhuman Primate Model.bioRxiv : the preprint server for biology · 2025Article
- Cancer progression through the lens of age-induced metabolic reprogramming.Nature reviews. Cancer · 2025Review
- Cumulative psychosocial factors and epigenetic age acceleration in the Hispanic Community Health Study/Study of Latinos.Epigenomics · 2025Article
- Racial Health Equity and the Question of Black (Non?) Being: Exploring the Uses of Afropessimism in Approaches to Anti-Racist Health Promotion.The British journal of sociology · 2025Article
- Oxytocin, Vasopressin and Stress: A Hormetic Perspective.Current issues in molecular biology · 2025Review
- Fine particulate matter air pollution and longitudinal gray matter development changes during early adolescence: variation by neighborhood disadvantage level.Environment international · 2025Article
- Effects of Walking and Barre Exercise on CES-D, Stress Hormones, hs-CRP, and Immunoglobulins in Elderly Women.Journal of clinical medicine · 2025Article
- The Potential of a Robot Presence in Close Relationship to Influence Human Responses to Experimental Pain.Life (Basel, Switzerland) · 2025Article
- Personality and Its Influence on Pain Sensitivity Based on Different Hormonal Responses to Individual vs. Group Exercise Styles.Life (Basel, Switzerland) · 2025Article
44 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The major neuroendocrine response mediating stress adaptation is activation of the hypothalamic pituitary adrenal axis, with stimulation of corticotropin releasing hormone (CRH) and vasopressin (VP) from parvocellular neurons of the hypothalamic paraventricular nucleus, leading to stimulation of pituitary ACTH secretion and increases in glucocorticoid secretion from the adrenal cortex. Basal production and transient increases during stress of glucocorticoids and its hypothalamic regulators are essential for neuronal plasticity and normal brain function. While activation of the HPA axis is essential for survival during stress, chronic exposure to stress hormones can predispose to psychological, metabolic and immune alterations. Thus, prompt termination of the stress response is essential to prevent negative effects of inappropriate levels of CRH and glucocorticoids. This review addresses the regulation of HPA axis activity with emphasis on the mechanisms of termination of CRH transcription, which is a critical step in this process. In addition, the actions by which glucocorticoids, CRH and VP can affect the aging process will be discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.