Evidence map›Paper›PMID 20832320›Full record

ReviewTrends in microbiology2010

CheV: CheW-like coupling proteins at the core of the chemotaxis signaling network.

Roger P Alexander, Andrew C Lowenthal, Rasika M Harshey, Karen M Ottemann

Abstract readReview
In one paragraph

Review in Trends in microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed.

  1. Article
  2. Trigger Factor inJournal of bacteriology · 2026
    Article
  3. TheJournal of bacteriology · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Journal of bacteriology · 2024
    Article
  13. Article
  14. The Complete Genome Sequence ofJournal of xenobiotics · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Eukaryotic catecholamine hormones influence the chemotactic control ofProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Roger P AlexanderDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
Andrew C Lowenthal
Rasika M Harshey
Karen M Ottemann

Funding

Training in Genomics and Proteomics TechnologiesT32HG003198 · NHGRI · YALE UNIVERSITY · PI BREAKER, RONALD R · 2004 to 2015
$4.9M
Roles for Motility in Helicobactor pylori pathogenesisR01AI050000 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI OTTEMANN, KAREN M · 2002 to 2011
$3.6M
Swarming as a model for surface-sensing in Salmonella typhimuriumR01GM057400 · NIGMS · UNIVERSITY OF TEXAS AUSTIN · PI HARSHEY, RASIKA M · 1998 to 2012
$2.5M
NHGRI NIH HHS T32 HG003198NHGRI NIH HHS T32-HG003198-04NIAID NIH HHS AI050000NIAID NIH HHS R01 AI050000NIGMS NIH HHS GM 57400NIGMS NIH HHS R01 GM057400
6 · The paper itself

Abstract

Microbes have chemotactic signaling systems that enable them to detect and follow chemical gradients in their environments. The core of these sensory systems consists of chemoreceptor proteins coupled to the CheA kinase via the scaffold or coupler protein CheW. Some bacterial chemotaxis systems replace or augment CheW with a related protein, CheV, which is less well understood. CheV consists of a CheW domain fused to a receiver domain that is capable of being phosphorylated. Our review of the literature, as well as comparisons of the CheV and CheW sequence and structure, suggest that CheV proteins conserve CheW residues that are crucial for coupling. Phosphorylation of the CheV receiver domain might adjust the efficiency of its coupling and thus allow the system to modulate the response to chemical stimuli in an adaptation process.

Indexed as

ChemotaxisSignal TransductionBacteriaBacterial ProteinsChemotactic FactorsPhosphorylationBacterial ProteinsChemotactic FactorscheV protein, bacteriaCheW protein, Bacteria

Identifiers

PMID20832320
PMCPMC2975053

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.