Trial reportDrug and alcohol dependence2011
Directly observed antiretroviral therapy improves adherence and viral load in drug users attending methadone maintenance clinics: a randomized controlled trial.
Trial report in Drug and alcohol dependence, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05039554 (Randomized Trial of Acceptance and Commitment Therapy), which is not on this map. Cited by 76 papers, 13 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Trial of Acceptance and Commitment Therapy (ACT) and a Care Management App in Primary Care-based Buprenorphine Treatment
Who cites it
76 citing papers in PubMed, 13 syntheses or guidelines pooled it.
- Interventions to enhance HIV medication adherence among individuals using substances: a systematic review and critique of the literature.AIDS care · 2026Pooled it
- Psychosocial Interventions to Promote Undetectable HIV Viral Loads: A Systematic Review of Randomized Clinical Trials.AIDS and behavior · 2022Pooled it
- A client-centered relational framework on barriers to the integration of HIV and substance use services: a systematic review.Harm reduction journal · 2019Pooled it
- Challenges in the Evaluation of Interventions to Improve Engagement Along the HIV Care Continuum in the United States: A Systematic Review.AIDS and behavior · 2017Pooled it
- Guideline
- Use of peers to improve adherence to antiretroviral therapy: a global network meta-analysis.Journal of the International AIDS Society · 2016Pooled it
- Evidence-based interventions to enhance assessment, treatment, and adherence in the chronic Hepatitis C care continuum.The International journal on drug policy · 2015Pooled it
- Interventions for enhancing medication adherence.The Cochrane database of systematic reviews · 2014Pooled it
- Identification of evidence-based interventions for promoting HIV medication adherence: findings from a systematic review of U.S.-based studies, 1996-2011.AIDS and behavior · 2014Pooled it
- A systematic review of antiretroviral adherence interventions for HIV-infected people who use drugs.Current HIV/AIDS reports · 2012Pooled it
- Guidelines for improving entry into and retention in care and antiretroviral adherence for persons with HIV: evidence-based recommendations from an International Association of Physicians in AIDS Care panel.Annals of internal medicine · 2012Guideline
- Social and structural factors associated with HIV disease progression among illicit drug users: a systematic review.AIDS (London, England) · 2012Pooled it
- Guideline
- Effect of varenicline directly observed therapy versus varenicline self-administered therapy on varenicline adherence and smoking cessation in methadone-maintained smokers: a randomized controlled trial.Addiction (Abingdon, England) · 2021Trial
- Abstinence-reinforcing contingency management improves HIV viral load suppression among HIV-infected people who use drugs: A randomized controlled trial.Drug and alcohol dependence · 2020Trial
- The impact of methadone maintenance therapy on access to regular physician care regarding hepatitis C among people who inject drugs.PloS one · 2018Trial
- Effect of directly observed antiretroviral therapy compared to self-administered antiretroviral therapy on adherence and virological outcomes among HIV-infected prisoners: a randomized controlled pilot study.AIDS and behavior · 2015Trial
- HIV risk reduction with buprenorphine-naloxone or methadone: findings from a randomized trial.Journal of acquired immune deficiency syndromes (1999) · 2014Trial
- Rationale and design of a randomized controlled trial of varenicline directly observed therapy delivered in methadone clinics.Addiction science & clinical practice · 2014Trial
- Trial
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectiveTo determine if directly observed antiretroviral therapy (DOT) is more efficacious than self-administered therapy for improving adherence and reducing HIV viral load (VL) among methadone-maintained opioid users.
designTwo-group randomized trial.
settingTwelve methadone maintenance clinics with on-site HIV care in the Bronx, New York.
participantsHIV-infected adults prescribed combination antiretroviral therapy. MAIN OUTCOMES MEASURES: Between group differences at four assessment points from baseline to week 24 in: (1) antiretroviral adherence measured by pill count, (2) VL, and (3) proportion with undetectable VL (< 75 copies/ml).
resultsBetween June 2004 and August 2007, we enrolled 77 participants. Adherence in the DOT group was higher than in the control group at all post-baseline assessment points; by week 24 mean DOT adherence was 86% compared to 56% in the control group (p < 0.0001). Group differences in mean adherence remained significant after stratifying by baseline VL (detectable versus undetectable). In addition, during the 24-week intervention, the proportion of DOT participants with undetectable VL increased from 51% to 71%.
conclusionsAmong HIV-infected opioid users, antiretroviral DOT administered in methadone clinics was efficacious for improving adherence and decreasing VL, and these improvements were maintained over a 24-week period. DOT should be more widely available to methadone patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.