Evidence map›Paper›PMID 20831431›Full record

ReviewJournal of women's health (2002)2010

Factors that may influence the experience of hot flushes by healthy middle-aged women.

Ayelet Ziv-Gal, Jodi A Flaws

Abstract readReview
In one paragraph

Review in Journal of women's health (2002), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Genetic Variation and Hot Flashes: A Systematic Review.The Journal of clinical endocrinology and metabolism · 2020
    Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Randomized, single-blind, placebo-controlled trial onIntegrative medicine research · 2022
    Article
  8. Article
  9. Hot Flashes in Adolescence and Young Adult Females: a Link to Vitamin D and Calcium.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2022
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Sleep and Methylation of Estrogen Receptor Genes,Nature and science of sleep · 2020
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Phthalate metabolite levels and menopausal hot flashes in midlife women.Reproductive toxicology (Elmsford, N.Y.) · 2016
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ayelet Ziv-GalDepartment of Veterinary Biosciences, University of Illinois, Urbana, Illinois 61802, USA.
Jodi A Flaws

Funding

Risk Factors for Hot Flashes in Mid-Life WomenR01AG018400 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI FLAWS, JODI A. · 2001 to 2011
$4.1M
NIA NIH HHS AG18400
6 · The paper itself

Abstract

backgroundInterest in menopausal symptoms in general and hot flushes (HFs) in particular has grown in recent years. This is mostly due to increased awareness and the vast impact these symptoms have on women's lives. Despite the high prevalence of women who experience HFs, a definitive etiology for HFs is yet to be found. Our objective was to review the current literature dealing with associated factors for experiencing HFs and to provide a synthesized overview on this common and often debilitating condition.

methodsWe systematically searched the English-language literature in the PubMed database using relevant key words and included only those articles that contained information on associated factors for HFs in generally healthy midlife women.

resultsBoth conflicting scientific results between studies documenting factors that influence HFs and the lack of validated measuring tools make it difficult to truly pinpoint associated factors for HFs. Nonetheless, we identified the following clusters of associated factors: the menopausal stages, sex steroid hormones, other endocrine agents, genetic polymorphisms, race/ethnicity, body mass index (BMI) and obesity, mood disorders, smoking, soy isoflavones and phytoestrogens, alcohol consumption, and physical activity.

conclusionsNo single associated factor was consistently identified as having a major role in experiencing HFs. More resources should be directed to develop a unified study system along with multivariable analyses to get a better understanding of this condition, which often imposes a tremendous social and personal toll on the women who experience it.

Indexed as

Health StatusAlcohol DrinkingFemaleGonadal Steroid HormonesHot FlashesHumansMenopauseMood DisordersPolymorphism, GeneticSmokingWomen's HealthGonadal Steroid Hormones

Identifiers

PMID20831431
PMCPMC2965699

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.