ArticleJournal of the American Chemical Society2010
Chemoselective attachment of small molecule effector functionality to human adenoviruses facilitates gene delivery to cancer cells.
Article in Journal of the American Chemical Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Review
- Bioorthogonal Surface Modification of Measles and Vaccinia Viruses Using Metabolic Azide Reporters.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Recent development of analytical methods for disease-specific proteinRSC advances · 2022Review
- Physical, chemical, and synthetic virology: Reprogramming viruses as controllable nanodevices.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2019Review
- A Spotlight on Viruses-Application of Click Chemistry to Visualize Virus-Cell Interactions.Molecules (Basel, Switzerland) · 2019Review
- Synthesis at the interface of virology and genetic code expansion.Current opinion in chemical biology · 2018Review
- Recent trends in click chemistry as a promising technology for virus-related research.Virus research · 2018Review
- Therapeutic applications of genetic code expansion.Synthetic and systems biotechnology · 2018Review
- Synthesis of a Novel Fluorescent Ruthenium Complex with an Appended Ac₄GlcNAc Moiety by Click Reaction.Molecules (Basel, Switzerland) · 2018Article
- Click labeling of unnatural sugars metabolically incorporated into viral envelope glycoproteins enables visualization of single particle fusion.Journal of virological methods · 2016Article
- Click chemistry in complex mixtures: bioorthogonal bioconjugation.Chemistry & biology · 2014Review
- Changes in metabolic chemical reporter structure yield a selective probe of O-GlcNAc modification.Journal of the American Chemical Society · 2014Article
- O-GlcNAc profiling: from proteins to proteomes.Clinical proteomics · 2014Article
- Applications of azide-based bioorthogonal click chemistry in glycobiology.Molecules (Basel, Switzerland) · 2013Review
- N-Propargyloxycarbamate monosaccharides as metabolic chemical reporters of carbohydrate salvage pathways and protein glycosylation.Chemical communications (Cambridge, England) · 2013Article
- Chemoselective modification of viral surfaces via bioorthogonal click chemistry.Journal of visualized experiments : JoVE · 2012Article
- Click chemistry for drug delivery nanosystems.Pharmaceutical research · 2012Review
- Targeted and armed oncolytic adenovirus via chemoselective modification.Bioorganic & medicinal chemistry letters · 2011Article
- Unnatural amino acid incorporation onto adenoviral (Ad) coat proteins facilitates chemoselective modification and retargeting of Ad type 5 vectors.Journal of virology · 2011Article
- Chemical reporters for fluorescent detection and identification of O-GlcNAc-modified proteins reveal glycosylation of the ubiquitin ligase NEDD4-1.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
We demonstrate here a novel two-step "click" labeling process in which adenoviral particles are first metabolically labeled during production with unnatural azido sugars. Subsequent chemoselective modification allows access to viruses decorated with a broad array of effector functionality. Adenoviruses modified with folate, a known cancer-targeting motif, demonstrated a marked increase in gene delivery to a murine cancer cell line.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.