ArticleAntonie van Leeuwenhoek2011
OmpR controls Yersinia enterocolitica motility by positive regulation of flhDC expression.
Article in Antonie van Leeuwenhoek, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Elucidating the mechanism of thiosulfate oxidation by a novel two-component system SulRS in deep-seaiScience · 2026Article
- The response regulator FpsR controls the flagella-pili transition and mucosal colonization inGut microbes · 2025Article
- Comparative pangenome analysis of Yersinia enterocolitica in a one health approach.BMC genomics · 2025Article
- The Regulatory Circuit Underlying Downregulation of a Type III Secretion System inInternational journal of molecular sciences · 2022Article
- Multiple Copies ofJournal of bacteriology · 2021Article
- The Regulator OmpR inInternational journal of molecular sciences · 2021Article
- In vitroMicroorganisms · 2020Article
- Osmoregulated Periplasmic Glucans Transmit External Signals Through Rcs Phosphorelay Pathway inFrontiers in microbiology · 2020Article
- Urease Expression in PathogenicFrontiers in microbiology · 2020Article
- The OmpR Regulator of Burkholderia multivorans Controls Mucoid-to-Nonmucoid Transition and Other Cell Envelope Properties Associated with Persistence in the Cystic Fibrosis Lung.Journal of bacteriology · 2018Article
- OmpR-Mediated Transcriptional Regulation and Function of Two Heme Receptor Proteins ofFrontiers in cellular and infection microbiology · 2018Article
- The EnvZ-OmpR Two-Component Signaling System Is Inactivated in a Mutant Devoid of Osmoregulated Periplasmic Glucans inFrontiers in microbiology · 2018Article
- The RNA Chaperone Hfq Is Essential for Virulence and Modulates the Expression of Four Adhesins in Yersinia enterocolitica.Scientific reports · 2016Article
- The Membrane Proteins Involved in Virulence of Cronobacter sakazakii Virulent G362 and Attenuated L3101 Isolates.Frontiers in microbiology · 2015Article
- Regulatory principles governing Salmonella and Yersinia virulence.Frontiers in microbiology · 2015Review
- Article
- Co-regulation of polysaccharide production, motility, and expression of type III secretion genes by EnvZ/OmpR and GrrS/GrrA systems in Erwinia amylovora.Molecular genetics and genomics : MGG · 2014Article
- Article
- OmpR, a response regulator of the two-component signal transduction pathway, influences inv gene expression in Yersinia enterocolitica O9.Frontiers in cellular and infection microbiology · 2012Article
- Modulation of inv gene expression by the OmpR two-component response regulator protein of Yersinia enterocolitica.Folia microbiologica · 2011Article
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4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flagella and invasin play important roles during the early stages of infection by the enteric pathogen Yersinia enterocolitica. Our previous study demonstrated that OmpR negatively regulates invasin gene expression at the transcriptional level. The present study focused on the role of OmpR in the regulation of flagella expression. Motility assays and microscopic observations revealed that an ompR mutant strain exhibits a non-motile phenotype due to the lack of flagella. An analysis of flhDC::lacZYA chromosomal fusions demonstrated a decrease in flhDC expression in ompR mutant cells, suggesting a role for OmpR in the positive control of flagellar master operon flhDC, which is in contrast to the negative role it plays in Escherichia coli. Moreover, high temperature or osmolarity and low pH decreased flhDC expression and OmpR was not required for the response to these factors. Evidence from an examination of the DNA binding properties of OmpR in vitro indicated that the mechanism by which OmpR regulates flhDC is direct. Electrophoretic mobility shift assays confirmed that OmpR binds specifically to the flhDC promoter region and suggested the presence of more than one OmpR-binding site. In addition, phosphorylation of OmpR by acetyl-P appeared to stimulate the binding abilities of OmpR. Together with the results of our previous studies revealing the negative role of OmpR in the regulation of invasin expression, these findings support a model in which invasion and motility might be reciprocally regulated by OmpR.
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