Evidence map›Paper›PMID 20830494›Full record

ReviewProtoplasma2011

Variations on theme: spindle assembly in diverse cells.

Patricia Wadsworth, Wei-Lih Lee, Takashi Murata, Tobias I Baskin

Open access · greenAbstract readReview
In one paragraph

Review in Protoplasma, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. AnBio-protocol · 2018
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Patricia WadsworthDepartment of Biology, Morrill Science Center, University of Massachusetts, Amherst, MA 01003, USA. patw@bio.umass.edu
Wei-Lih Lee
Takashi Murata
Tobias I Baskin
University of Massachusetts Amherst · USNational Institute for Basic Biology · JP

Funding

Mechanism of Dynein-Mediated Spindle PositioningR01GM076094 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI LEE, WEI-LIH · 2007 to 2016
$3.1M
Mechanisms of Microtubule Dynamic TurnoverR01GM059057 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI WADSWORTH, PATRICIA · 2000 to 2009
$2.2M
NIGMS NIH HHS GM 059057NIGMS NIH HHS GM076094NIGMS NIH HHS R01 GM059057NIGMS NIH HHS R01 GM076094
6 · The paper itself

Abstract

The mitotic spindle faithfully separates the genetic material, and has been reverently observed for well over a century. Across eukaryotes, while the mechanisms for moving chromosomes seem quite conserved, mechanisms for assembling the spindle often seem distinct. Two major pathways for spindle assembly are known, one based on centrosomes and the other based on chromatin, and these pathways are usually considered to be fundamentally different. We review observations of spindle assembly in animals, fungi, and plants, and argue that microtubule assembly at a particular location, centrosomes, or chromatin, reflects contingent, cell-type specific factors, rather than reflecting a fundamental distinction in the process of spindle building. We hypothesize that the essential process for spindle assembly is the motor-driven organization of microtubules that accumulate in the form of dense bundles at or near the chromosomes.

Indexed as

AnimalsCentrosomeHumansPlantsSpindle ApparatusYeasts

Identifiers

PMID20830494
PMCPMC5290749
OpenAlexW2079462653

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.