ArticlePloS one2010
Expression profiling of a genetic animal model of depression reveals novel molecular pathways underlying depressive-like behaviours.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Genetic Liability for Internalizing Versus Externalizing Behavior Manifests in the Developing and Adult Hippocampus: Insight From a Meta-analysis of Transcriptional Profiling Studies in a Selectively Bred Rat Model.Biological psychiatry · 2021Pooled it
- Neuron-specific expression of transmembrane protein 130 (TMEM130).Scientific reports · 2026Article
- Astrocyte fatty acid metabolism as a driver of risk for major depressive disorder.Nature communications · 2026Article
- Transcriptomic Insights into Late-Life Depression and the Role of Environmental Drinking Water Composition: A Study on 18-Month-Old Mice.International journal of molecular sciences · 2025Article
- Bioenergetic-related gene expression in the hippocampus predicts internalizing vs. externalizing behavior in an animal model of temperament.Frontiers in molecular neuroscience · 2025Article
- Article
- Resource: A Curated Database of Brain-Related Functional Gene Sets (Brain.GMT).bioRxiv : the preprint server for biology · 2024Article
- Roles, molecular mechanisms, and signaling pathways of TMEMs in neurological diseases.American journal of translational research · 2021Review
- Statins and the Brain: More than Lipid Lowering Agents?Current neuropharmacology · 2019Review
- Cross-species evidence from human and rat brain transcriptome for growth factor signaling pathway dysregulation in major depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Distinct Expression and Prognostic Value of MS4A in Gastric Cancer.Open medicine (Warsaw, Poland) · 2018Article
- Exome sequences of multiplex, multigenerational families reveal schizophrenia risk loci with potential implications for neurocognitive performance.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017Article
- Ketamine and Beyond: Investigations into the Potential of Glutamatergic Agents to Treat Depression.Drugs · 2017Review
- MicroRNA 101b Is Downregulated in the Prefrontal Cortex of a Genetic Model of Depression and Targets the Glutamate Transporter SLC1A1 (EAAT3) in Vitro.The international journal of neuropsychopharmacology · 2016Article
- Behavioural and biochemical changes in maternally separated Sprague-Dawley rats exposed to restraint stress.Metabolic brain disease · 2016Article
- Review
- Identification of genes and gene pathways associated with major depressive disorder by integrative brain analysis of rat and human prefrontal cortex transcriptomes.Translational psychiatry · 2015Article
- Article
- Simvastatin treatment highlights a new role for the isoprenoid/cholesterol biosynthetic pathway in the modulation of emotional reactivity and cognitive performance in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Effects of L-theanine on posttraumatic stress disorder induced changes in rat brain gene expression.TheScientificWorldJournal · 2014Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe Flinders model is a validated genetic rat model of depression that exhibits a number of behavioural, neurochemical and pharmacological features consistent with those observed in human depression. PRINCIPAL
findingsIn this study we have used genome-wide microarray expression profiling of the hippocampus and prefrontal/frontal cortex of Flinders Depression Sensitive (FSL) and control Flinders Depression Resistant (FRL) lines to understand molecular basis for the differences between the two lines. We profiled two independent cohorts of Flinders animals derived from the same colony six months apart, each cohort statistically powered to allow independent as well as combined analysis. Using this approach, we were able to validate using real-time-PCR a core set of gene expression differences that showed statistical significance in each of the temporally distinct cohorts, representing consistently maintained features of the model. Small but statistically significant increases were confirmed for cholinergic (chrm2, chrna7) and serotonergic receptors (Htr1a, Htr2a) in FSL rats consistent with known neurochemical changes in the model. Much larger gene changes were validated in a number of novel genes as exemplified by TMEM176A, which showed 35-fold enrichment in the cortex and 30-fold enrichment in hippocampus of FRL animals relative to FSL.
conclusionsThese data provide significant insights into the molecular differences underlying the Flinders model, and have potential relevance to broader depression research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.