ArticleThe Korean journal of internal medicine2010
High-dose fentanyl patch for cancer pain of a patient with cholangiocarcinoma.
Article in The Korean journal of internal medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Guidelines for Rational Clinical Use of Fentanyl Transdermal Patch.Drug design, development and therapy · 2024Article
- Characterization of QTLs and Candidate Genes for Days to Heading in Rice Recombinant Inbred Lines.Genes · 2020Article
- The Incidence of Severe Diarrhea with Transdermal Fentanyl Patch: An Uncommon Event.Journal of clinical and diagnostic research : JCDR · 2015Article
- Efficacy of fentanyl transdermal patch in the treatment of chronic soft tissue cancer pain.Anesthesiology and pain medicine · 2015Article
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Authors and funding
7 authors at 1 institution in 1 country.
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Abstract
We describe here a patient who obtained a good analgesic effect with high-dose fentanyl patches for controlling cancer pain. A 52-year-old man was referred to our hospital because of severe cancer pain that was 7/10 on a numeric rating scale (NRS). He had been diagnosed with locally advanced cholangiocarcinoma 3 months previously. We prescribed weak opioids and an antidepressant, but his pain was not relieved. We introduced strong opioids (transdermal fentanyl patches for the background pain and a short-acting opioid for the breakthrough pain) and his pain was tolerable on 250 µg/hr of fentanyl patches for 3 months. With time, however, his pain intensity became worse and this reached up to 8/10 to 9/10 on the NRS. Percutaneous transhepatic biliary drainage was performed, which did not relieve his pain. We increased gradually the dose of transdermal fentanyl to 1,050 µg/hr (20 patches). At this dose, the patient was mentally alert, with good pain control (NRS 2/10 to 3/10) and no exacerbation of side effects. To the best of our knowledge, we report here on the highest dose of transdermal fentanyl that has been successfully used for treating a patient suffering from visceral cancer pain.
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