ArticleInvestigative radiology2010
Evaluation of renal hypoxia in diabetic mice by BOLD MRI.
Article in Investigative radiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 59 citations in OpenAlex.
- Renal oxygen content is increased in healthy subjects after angiotensin-converting enzyme inhibition.Clinics (Sao Paulo, Brazil) · 2012Trial
- 3D autofluorescence imaging of hydronephrosis and renal anatomical structure using cryo-micro-optical sectioning tomography.Theranostics · 2023Article
- Alterations of Renal Function in Patients with Diabetic Kidney Disease: A BOLD and DTI Study.Computational intelligence and neuroscience · 2022Article
- MRI Mapping of the Blood Oxygenation Sensitive Parameter TMethods in molecular biology (Clifton, N.J.) · 2021Article
- Susceptibility weighted imaging (SWI) for evaluating renal dysfunction in type 2 diabetes mellitus: a preliminary study using SWI parameters and SWI-based texture features.Annals of translational medicine · 2020Article
- Characterizing the Retinal Phenotype in the High-Fat Diet and Western Diet Mouse Models of Prediabetes.Cells · 2020Article
- Non-invasive assessment of early stage diabetic nephropathy by DTI and BOLD MRI.The British journal of radiology · 2020Article
- Evaluation of Renal Pathophysiological Processes Induced by an Iodinated Contrast Agent in a Diabetic Rabbit Model Using Intravoxel Incoherent Motion and Blood Oxygenation Level-Dependent Magnetic Resonance Imaging.Korean journal of radiology · 2019Article
- Quantitative photoacoustic imaging study of tumours in vivo: Baseline variations in quantitative measurements.Photoacoustics · 2019Article
- Resveratrol Protects Against Post-Contrast Acute Kidney Injury in Rabbits With Diabetic Nephropathy.Frontiers in pharmacology · 2019Article
- BOLD MRI to evaluate early development of renal injury in a rat model of diabetes.The Journal of international medical research · 2018Article
- Assessment of unilateral ureter obstruction with multi-parametric MRI.Magnetic resonance in medicine · 2018Article
- Comprehensive renoprotective effects of ipragliflozin on early diabetic nephropathy in mice.Scientific reports · 2018Article
- Effect of anesthesia on renal R2 * measured by blood oxygen level-dependent MRI.NMR in biomedicine · 2015Article
- Sleep fragmentation has differential effects on obese and lean mice.Journal of molecular neuroscience : MN · 2015Article
- Longitudinal assessment of mouse renal injury using high-resolution anatomic and magnetization transfer MR imaging.Magnetic resonance imaging · 2014Article
- Article
- New magnetic resonance imaging methods in nephrology.Kidney international · 2014Review
- Blood oxygenation level-dependent MRI for assessment of renal oxygenation.International journal of nephrology and renovascular disease · 2014Review
- Determinants of renal tissue oxygenation as measured with BOLD-MRI in chronic kidney disease and hypertension in humans.PloS one · 2014Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
objectiveRenal hypoxia has been proposed to be a pathophysiologic feature of diabetic kidney disease but it has been difficult to demonstrate in vivo, particularly in mouse models of diabetes. The objective of this work was to examine the sensitivity of blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) to assess renal oxygenation in vivo in a mouse model of diabetic kidney disease, the db/db mice. RESEARCH DESIGN AND
methodsKidney BOLD MRI studies were performed on a 3.0 T scanner using multiple gradient echo sequence with a custom-designed surface coil to acquire T2*-weighted images. Studies were performed in 10-week-old db/db mice (n = 7) and db/m controls (n = 6).
resultsR2* is a measure of the tissue deoxyhemoglobin concentration and higher values of R2* are associated with hypoxia. The db/db mice had higher medullary (43.1 ± 5.1 s⁻¹ vs. 32.3 ± 3.7⁻¹ s, P = 0.001) and cortical R2* (31.7 ± 3.1 s⁻¹ vs. 27.1 ± 4.1 s⁻¹, P = 0.04) values. Using pimonidazole staining as a marker of kidney hypoxia, in kidney sections from 10-week-old db/db mice neither cortex nor medulla had significant differences as compared with 10-week-old db/m mice (cortex: db/db 2.14 ± 0.05 vs. db/m 2.02 ± 0.28, medulla: db/db 2.81 ± 0.08 vs. db/m 2.6 ± 0.08). The db/db mice demonstrated further increased cortical and medullary hypoxia when scanned again at 15 weeks of age.
conclusionsThe report shows that renal BOLD MRI is a sensitive method for the in vivo evaluation of renal hypoxia in a mouse model of diabetic kidney disease where progressive renal hypoxia can be documented over time. BOLD MRI may be useful to monitor therapeutic interventions that may improve tissue hypoxia in the diabetic kidney.
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