ArticleJournal of applied physiology (Bethesda, Md. : 1985)2010
ATP and the purine type 2 X7 receptor affect sleep.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
53 citing papers in PubMed, 87 citations in OpenAlex.
- Innate immune mechanisms of infection: what we know and potential conserved mechanisms affecting sleep during infection.Neurobiology of sleep and circadian rhythms · 2025Article
- Review
- Microglial TNFα controls daily changes in synaptic GABAARs and sleep slow waves.The Journal of cell biology · 2024Article
- Microglial Regulation of Sleep and Wakefulness.Advances in neurobiology · 2024Review
- Tripping on the edge of consciousness.Sleep advances : a journal of the Sleep Research Society · 2023Article
- P2X7 receptor-activated microglia in cortex is critical for sleep disorder under neuropathic pain.Frontiers in neuroscience · 2023Article
- Translational approaches to influence sleep and arousal.Brain research bulletin · 2022Review
- Microglia are involved in the protection of memories formed during sleep deprivation.Neurobiology of sleep and circadian rhythms · 2022Article
- Sleep, Narcolepsy, and Sodium Oxybate.Current neuropharmacology · 2022Article
- Neuroinflammation, Sleep, and Circadian Rhythms.Frontiers in cellular and infection microbiology · 2022Review
- Microglia modulate hippocampal synaptic transmission and sleep duration along the light/dark cycle.Glia · 2022Article
- Microglia and the Aging Brain: Are Geriatric Microglia Linked to Poor Sleep Quality?International journal of molecular sciences · 2021Review
- From Physiology to Pathology of Cortico-Thalamo-Cortical Oscillations: Astroglia as a Target for Further Research.Frontiers in neurology · 2021Review
- Sleep deprivation, vigilant attention, and brain function: a review.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Review
- Interleukin-1 receptor accessory proteins are required for normal homeostatic responses to sleep deprivation.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Activation of basal forebrain purinergic P2 receptors promotes wakefulness in mice.Scientific reports · 2018Article
- Circadian rhythm and sleep-wake systems share the dynamic extracellular synaptic milieu.Neurobiology of sleep and circadian rhythms · 2018Review
- Is Adenosine Action Common Ground for NREM Sleep, Torpor, and Other Hypometabolic States?Physiology (Bethesda, Md.) · 2018Review
- Purinergic Signaling in Neuron-Astrocyte Interactions, Circadian Rhythms, and Alcohol Use Disorder.Frontiers in physiology · 2018Review
- Heterozygosity for the Mood Disorder-Associated Variant Gln460Arg Alters P2X7 Receptor Function and Sleep Quality.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Sleep is dependent upon prior brain activities, e.g., after prolonged wakefulness sleep rebound occurs. These effects are mediated, in part, by humoral sleep regulatory substances such as cytokines. However, the property of wakefulness activity that initiates production and release of such substances and thereby provides a signal for indexing prior waking activity is unknown. We propose that extracellular ATP, released during neuro- and gliotransmission and acting via purine type 2 (P2) receptors, is such a signal. ATP induces cytokine release from glia. Cytokines in turn affect sleep. We show here that a P2 receptor agonist, 2'(3')-O-(4-benzoylbenzoyl)adenosine 5'-triphosphate (BzATP), increased non-rapid eye movement sleep (NREMS) and electroencephalographic (EEG) delta power while two different P2 receptor antagonists, acting by different inhibitory mechanisms, reduced spontaneous NREMS in rats. Rat P2X7 receptor protein varied in the somatosensory cortex with time of day, and P2X7 mRNA was altered by interleukin-1 treatment, by sleep deprivation, and with time of day in the hypothalamus and somatosensory cortex. Mice lacking functional P2X7 receptors had attenuated NREMS and EEG delta power responses to sleep deprivation but not to interleukin-1 treatment compared with wild-type mice. Data are consistent with the hypothesis that extracellular ATP, released as a consequence of cell activity and acting via P2 receptors to release cytokines and other sleep regulatory substances, provides a mechanism by which the brain could monitor prior activity and translate it into sleep.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.