ArticleBriefings in functional genomics2010
Identification and resolution of artifacts in the interpretation of imprinted gene expression.
Article in Briefings in functional genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Evolution of Gene Expression Across Functional Regions of the Mouse Placenta.Genome biology and evolution · 2026Article
- Article
- Dynamics of the Equine Placental DNA Methylome and Transcriptome from Mid- to Late Gestation.International journal of molecular sciences · 2023Article
- Parental bias in expression and interaction of genes in the equine placenta.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Article
- Parent-of-origin effects on quantitative phenotypes in a large Hutterite pedigree.Communications biology · 2019Article
- Article
- RNA2DNAlign: nucleotide resolution allele asymmetries through quantitative assessment of RNA and DNA paired sequencing data.Nucleic acids research · 2016Article
- Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners.PloS one · 2016Article
- Allelome.PRO, a pipeline to define allele-specific genomic features from high-throughput sequencing data.Nucleic acids research · 2015Article
- The landscape of genomic imprinting across diverse adult human tissues.Genome research · 2015Article
- Allelic Imbalance Is a Prevalent and Tissue-Specific Feature of the Mouse Transcriptome.Genetics · 2015Article
- Review
- Review
- DNMT1 and AIM1 Imprinting in human placenta revealed through a genome-wide screen for allele-specific DNA methylation.BMC genomics · 2013Article
- Imprinted silencing is extended over broad chromosomal domains in mouse extra-embryonic lineages.Current opinion in cell biology · 2013Review
- Article
- Differentiation-driven nucleolar association of the mouse imprinted Kcnq1 locus.G3 (Bethesda, Md.) · 2012Article
- A genome-wide approach reveals novel imprinted genes expressed in the human placenta.Epigenetics · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genomic imprinting refers to genes that are epigenetically programmed in the germline to express exclusively or preferentially one allele in a parent-of-origin manner. Expression-based genome-wide screening for the identification of imprinted genes has failed to uncover a significant number of new imprinted genes, probably because of the high tissue- and developmental-stage specificity of imprinted gene expression. A very large number of technical and biological artifacts can also lead to the erroneous evidence of imprinted gene expression. In this article, we focus on three common sources of potential confounding effects: (i) random monoallelic expression in monoclonal cell populations, (ii) genetically determined monoallelic expression and (iii) contamination or infiltration of embryonic tissues with maternal material. This last situation specifically applies to genes that occur as maternally expressed in the placenta. Beside the use of reciprocal crosses that are instrumental to confirm the parental specificity of expression, we provide additional methods for the detection and elimination of these situations that can be misinterpreted as cases of imprinted expression.
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