Trial reportContemporary clinical trials2011
A randomized trial of genetic and environmental risk assessment (GERA) for colorectal cancer risk in primary care: trial design and baseline findings.
Trial report in Contemporary clinical trials, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00478309 (Gene Environment Risk Assessment and CRC Screening), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Gene Environment Risk Assessment and CRC Screening
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The impact of communicating genetic risks of disease on risk-reducing health behaviour: systematic review with meta-analysis.BMJ (Clinical research ed.) · 2016Pooled it
- Genetic and environmental risk assessment and colorectal cancer screening in an average-risk population: a randomized trial.Annals of internal medicine · 2014Trial
- Primary care patient interests in joining a planned multi-cancer early detection clinical trial.Cancer medicine · 2024Article
- Effects of genetic and environmental risk assessment feedback on colorectal cancer screening adherence.Journal of behavioral medicine · 2015Article
- "Is it really worth it to get tested?": primary care patients' impressions of predictive SNP testing for colon cancer.Journal of genetic counseling · 2013Article
- Predictors of patient uptake of colorectal cancer gene environment risk assessment.Genome medicine · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
purposeThis paper describes an ongoing randomized controlled trial designed to assess the impact of genetic and environmental risk assessment (GERA) on colorectal cancer (CRC) screening.
methodsThe trial includes asymptomatic patients who are 50-79years and are not up-to-date with CRC screening guidelines. Patients who responded to a baseline telephone survey are randomized to a GERA or Control group. GERA group participants meet with a nurse, decide whether to have a GERA blood test (a combination of genetic polymorphism and folate), and, if tested, receive GERA feedback. Follow-up telephone surveys are conducted at 1 and 6months. A chart audit is performed at 6months.
resultsOf 2,223 eligible patients, 562 (25%) have enrolled. Patients who enrolled in the study were significantly younger than those who did not (p<0.001). Participants tended to be 50-59years (64%), female (58%), white (52%), married (51%), and have more than a high school education (67%). At baseline, most participants had some knowledge of CRC screening and GERA, viewed CRC screening favorably, and reported that they had decided to do screening. Almost half had worries and concerns about CRC.
conclusionsOne in four eligible primary care patients enrolled in the study. Age was negatively associated with enrollment. Prospective analyses using data for all participants will provide more definitive information on GERA uptake and the impact of GERA feedback.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.