ArticleStem cells (Dayton, Ohio)2010
The Wnt/β-catenin signaling pathway tips the balance between apoptosis and reprograming of cell fusion hybrids.
Article in Stem cells (Dayton, Ohio), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis.Stem cell research & therapy · 2019Article
- The Pleiotropic Effects of the Canonical Wnt Pathway in Early Development and Pluripotency.Genes · 2018Review
- Mesenchymal stem cells generate distinct functional hybrids in vitro via cell fusion or entosis.Scientific reports · 2016Article
- Survivin Improves Reprogramming Efficiency of Human Neural Progenitors by Single Molecule OCT4.Stem cells international · 2016Article
- Temporal perturbation of the Wnt signaling pathway in the control of cell reprogramming is modulated by TCF1.Stem cell reports · 2014Article
- β-catenin/Tcf-signaling appears to establish the murine ovarian surface epithelium (OSE) and remains active in selected postnatal OSE cells.BMC developmental biology · 2012Article
- Tumor associated macrophage × cancer cell hybrids may acquire cancer stem cell properties in breast cancer.PloS one · 2012Article
- Activated β-catenin forces N2A cell-derived neurons back to tumor-like neuroblasts and positively correlates with a risk for human neuroblastoma.International journal of biological sciences · 2012Article
- Wnt/β-catenin signaling in embryonic stem cell self-renewal and somatic cell reprogramming.Stem cell reviews and reports · 2011Review
- T-cell factor 3 (Tcf3) deletion increases somatic cell reprogramming by inducing epigenome modifications.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Cell-cell fusion contributes to cell differentiation and developmental processes. We have previously showed that activation of Wnt/β-catenin enhances somatic cell reprograming after polyethylene glycol (PEG)-mediated fusion. Here, we show that neural stem cells and ESCs can fuse spontaneously in cocultures, although with very low efficiency (about 2%), as the hybrids undergo apoptosis. In contrast, when Wnt/β-catenin signaling is activated in ESCs and leads to accumulation of low amounts of β-catenin in the nucleus, activated ESCs can reprogram somatic cells with very high efficiency after spontaneous fusion. Furthermore, we also show that different levels of β-catenin accumulation in the ESC nuclei can modulate cell proliferation, although in our experimental setting, cell proliferation does not modulate the reprograming efficiency per se. Overall, the present study provides evidence that spontaneous fusion occurs, while the survival of the reprogramed clones is strictly dependent on induction of a Wnt-mediated reprograming pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.