Evidence map›Paper›PMID 20827592›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2010

Sequence analysis of chromatin immunoprecipitation data for transcription factors.

Kenzie D Macisaac, Ernest Fraenkel

Abstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Targeting H3K4 trimethylation in Huntington disease.Proceedings of the National Academy of Sciences of the United States of America · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kenzie D MacisaacDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. kenzie_macisaac@merck.edu
Ernest Fraenkel
Massachusetts Institute of Technology · US

Funding

A Systems Biology Approach to Reveal Huntington's Disease MechanismsR01GM089903 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FRAENKEL, ERNEST · 2010 to 2014
$2.4M
NIGMS NIH HHS R01 GM089903
6 · The paper itself

Abstract

Chromatin immunoprecipitation (ChIP) experiments allow the location of transcription factors to be determined across the genome. Subsequent analysis of the sequences of the identified regions allows binding to be localized at a higher resolution than can be achieved by current high-throughput experiments without sequence analysis and may provide important insight into the regulatory programs enacted by the protein of interest. In this chapter we review the tools, workflow, and common pitfalls of such analyses and recommend strategies for effective motif discovery from these data.

Indexed as

Binding SitesChromatin ImmunoprecipitationChromosome MappingDNARegulatory Sequences, Nucleic AcidSequence Analysis, DNASubstrate SpecificityTranscription FactorsDNATranscription Factors

Identifiers

PMID20827592
PMCPMC3922641
OpenAlexW196252411

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.