ArticleVirchows Archiv : an international journal of pathology2010
Immunohistochemical analysis of pyloric gland adenomas using a series of Mucin 2, Mucin 5AC, Mucin 6, CD10, Ki67 and p53.
Article in Virchows Archiv : an international journal of pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 70 citations in OpenAlex.
- Article
- Subtype-specific risk factors for gastric adenomas and independent predictors of recurrence after endoscopic resection.World journal of gastrointestinal endoscopy · 2025Article
- Evaluating Malignant Potential of Gastric Adenomas: The Role of Endoscopic Features and Genetic Alterations.Journal of gastroenterology and hepatology · 2025Article
- Clinicopathological characteristics of 30 cases of pyloric gland adenoma: a single center case series.BMC gastroenterology · 2025Article
- Detached pyloric gland adenoma of gallbladder: A case report and review of literature.Clinical case reports · 2024Article
- A case of gastric adenocarcinoma with pyloric gland-type infiltrating submucosa.Surgical case reports · 2024Article
- Gastric foveolar adenoma in the duodenal bulb: case report.The Pan African medical journal · 2024Article
- Pyloric Gastric Adenoma: Endoscopic Detection, Removal, and Echoendosonographic Characterization.ACG case reports journal · 2023Article
- Multifocal Pyloric Gland Adenoma of the Esophagus Treated by Circumferential Endoscopic Submucosal Dissection.ACG case reports journal · 2023Article
- Pyloric Gland Adenoma of the Esophagus Treated by Endoscopic Submucosal Dissection: A Case Report.Gut and liver · 2022Article
- Article
- Article
- Silencing of A-kinase anchor protein 4 inhibits the metastasis and growth of non-small cell lung cancer.Bioengineered · 2022Article
- Pyloric gland adenoma with low-grade intraepithelial neoplasia: A case report and literature review.Medicine · 2021Review
- Helicobacter Infection and Gastric Adenoma.Microorganisms · 2021Article
- Gastric pyloric gland adenoma resembling a submucosal tumor: A case report.World journal of clinical cases · 2020Article
- Impact of gastroesophageal reflux control through tailored proton pump inhibition therapy or fundoplication in patients with Barrett's esophagus.World journal of gastroenterology · 2017Article
- [Precursors of gastric cancer : Dysplasia and adenoma].Der Pathologe · 2017Review
- Morphology and genetics of pyloric gland adenomas in familial adenomatous polyposis.Histopathology · 2017Article
- Mitochondrial DNA alterations in the progression of gastric carcinomas: unexplored issues and future research needs.World journal of gastroenterology · 2014Review
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A pyloric gland adenoma (PGA) of the stomach was first described in a book chapter in 1976 by Kurt Elster and has been rarely reported in the literature. We expanded the current immunohistochemical data of these adenomas in a detailed series to further analyse the immunhistochemical status of PGA. From 60 patients with PGA with and without adenocarcinomas of the gastrointestinal tract, an immunhistochemical panel of Mucin 2, Mucin 5AC, Mucin 6, CD10, Ki67 and p53 was used to define the expression of these markers. All PGA were positive for Mucin 6 (deep mucoid glands), which they express over the whole lesion up to the surface. Mucin 5AC expression varies from case to case. A transition from gastric to intestinal differentiation can be observed focally as depicted by Mucin 2 and CD10 in 65% of the cases. The gastric corpus mucosa of elderly patients with either Helicobacter pylori gastritis or autoimmune gastritis is highly affected. Almost 47% of all PGA already underwent malignant transformation into adenocarcinoma. Significant immunohistochemical differences could be detected between PGA with and without adenocarcinoma regarding ki67 and p53. The diagnosis of PGA can be confirmed immunohistochemically by staining against apomucin 6 and apomucin 5AC. Focal intestinal differentiation supports the hypothesis that gastric adenocarcinomas can initially develop from carcinomas of the gastric type and transform into intestinal type later on. The high frequency of malignant transformation of PGA underlines its high potential for invasive malignancy.
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