Evidence map›Paper›PMID 20827374›Full record

ReviewmBio2010

Analogous telesensing pathways regulate mating and virulence in two opportunistic human pathogens.

Richard J Bennett, Gary M Dunny

Open access · goldAbstract readReview
In one paragraph

Review in mBio, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. The Characterization ofOpen medicine (Warsaw, Poland) · 2020
    Article
  3. Article
  4. Article
  5. Microorganism and filamentous fungi drive evolution of plant synapses.Frontiers in cellular and infection microbiology · 2013
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Richard J BennettDepartment of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA. richard_bennett@brown.edu
Gary M Dunny
Brown University · USUniversity of Minnesota · US

Funding

Transcriptional Regulation of C. albicans Cell Fate and Host InteractionsR01AI081704 · NIAID · BROWN UNIVERSITY · PI Richard John Bennett · 2010 to 2026
$6.4M
GENETIC FUNCTIONS OF CONJUGATIVE STREPTOCOCCAL R FACTORR01GM049530 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI DUNNY, GARY M · 1992 to 2014
$3.6M
Biofilms and Enterococcus faecalis BiologyR01AI058134 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI DUNNY, GARY M · 2005 to 2015
$3.6M
Phenotypic Switching in Candida albicans and its Role in PathogenesisR21AI081560 · NIAID · BROWN UNIVERSITY · PI BENNETT, RICHARD JOHN · 2009 to 2010
$442k
Biofilms and Enterococcus faecalis BiologyR56AI058134 · NIAID · UNIVERSITY OF MINNESOTA · PI DUNNY, GARY M · 2010 to 2010
$389k
NIAID NIH HHS 2R01AI058134NIAID NIH HHS R01 AI058134NIAID NIH HHS R01 AI081704NIAID NIH HHS R01AI081704NIAID NIH HHS R21 AI081560NIAID NIH HHS R21AI081560NIAID NIH HHS R56 AI058134NIGMS NIH HHS 2R01GM049530NIGMS NIH HHS R01 GM049530
6 · The paper itself

Abstract

Telesensing, or probing of the environment by the release of chemical messengers, plays a central role in the sexual programs of microbial organisms. Sex pheromones secreted by mating cells are sensed by potential partner cells and mediate cell-to-cell contact and the subsequent exchange of genetic material. Although the mechanisms used by bacterial and fungal species to promote genetic exchange are distinct, recent studies have uncovered surprising parallels between pheromone signaling in these species. In addition, it is now apparent that pheromone signaling not only controls sexual reproduction and genetic exchange but can also activate expression of potential virulence factors in diverse opportunistic pathogens.

Indexed as

Conjugation, GeneticSignal TransductionAnimalsCandida albicansCandidiasisEnterococcus faecalisGram-Positive Bacterial InfectionsHumansPheromonesReproductionVirulencePheromones

Identifiers

PMID20827374
PMCPMC2934609
OpenAlexW2102221321

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.