ArticleInternational journal of rheumatology2010
Lower extremity ulcers in systemic sclerosis: features and response to therapy.
Article in International journal of rheumatology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 64 citations in OpenAlex.
- Diabetic foot ulcer with overlap syndrome: A case report and review of literature.World journal of diabetes · 2025Article
- Article
- Rab7 inhibitor enhances stem cell differentiation into keratinocyte-like cells with anti-inflammatory properties.Frontiers in immunology · 2025Article
- Lower limb ulcer and Raynaud's phenomenon.JAAD case reports · 2022Article
- Microangiopathy in Inflammatory Diseases-Strategies in Surgery of the Lower Extremity.Life (Basel, Switzerland) · 2022Article
- Successful Use of Hyperbaric Oxygen as Adjunctive Therapy for a Nonhealing Venous Ulcer in a Patient with Systemic Sclerosis and Pulmonary Arterial Hypertension: A Case Report and Review of the Literature.Case reports in pulmonology · 2020Article
- Review of local wound management for scleroderma-associated digital ulcers.Journal of scleroderma and related disorders · 2018Article
- The financial and quality-of-life cost to patients living with a chronic wound in the community.International wound journal · 2017Article
- Points to consider for skin ulcers in systemic sclerosis.Rheumatology (Oxford, England) · 2017Review
- A 66-Year-Old Woman With Hemoptysis.Arthritis care & research · 2017Article
- Vasculitic and autoimmune wounds.Journal of vascular surgery. Venous and lymphatic disorders · 2017Review
- Relationship between opioid treatment and rate of healing in chronic wounds.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2017Observational
- Vasculitic Diseases and Prothrombotic States Contributing to Delayed Healing In Chronic Wounds.Current dermatology reports · 2016Article
- Systemic sclerosis chronic ulcers: preliminary results of treatment with allogenic skin grafting in a cohort of Italian patients.International wound journal · 2016Article
- Digital ulcers in scleroderma patients: A retrospective observational study.International journal of immunopathology and pharmacology · 2016Observational
- Clinical characteristics of foot ulceration in people with chronic gout.International wound journal · 2016Article
- Systemic sclerosis: current concepts in pathogenesis and therapeutic aspects of dermatological manifestations.Indian journal of dermatology · 2013Article
- Peripheral neuropathy: a complication of systemic sclerosis.Clinical rheumatology · 2013Article
- Successful treatment with bosentan of lower extremity ulcers in a scleroderma patient.Case reports in medicine · 2013Article
- Prevalence of immune disease in patients with wounds presenting to a tertiary wound healing centre.International wound journal · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nondigital lower extremity ulcers are a difficult to treat complication of scleroderma, and a significant cause of morbidity. The purpose of this study was to evaluate the prevalence of nondigital lower extremity ulcers in scleroderma and describe the associations with autoantibodies and genetic prothrombotic states. A cohort of 249 consecutive scleroderma patients seen in the Georgetown University Hosptial Division of Rheumatology was evaluated, 10 of whom had active ulcers, giving a prevalence of 4.0%. Patients with diffuse scleroderma had shorter disease duration at the time of ulcer development (mean 4.05 years ± 0.05) compared to those with limited disease (mean 22.83 years ± 5.612, P value .0078). Ulcers were bilateral in 70%. In the 10 patients with ulcers, antiphospholipid antibodies were positive in 50%, and genetic prothrombotic screen was positive in 70% which is higher than expected based on prevalence reports from the general scleroderma population. Of patients with biopsy specimens available (n = 5), fibrin occlusive vasculopathy was seen in 100%, and all of these patients had either positive antiphospholipid antibody screen, or positive genetic prothrombotic profile. We recommend screening scleroderma patients with lower extremity ulcers for the presence of anti-phospholipid antibodies and genetic prothrombotic states.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.