ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2010
Astrocytes are 'good scouts': being prepared also helps neighboring neurons.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Article
- Metabolic Contribution and Cerebral Blood Flow Regulation by Astrocytes in the Neurovascular Unit.Cells · 2022Review
- Neuroprotection and Disease Modification by Astrocytes and Microglia in Parkinson Disease.Antioxidants (Basel, Switzerland) · 2022Review
- Metabolic compartmentalization between astroglia and neurons in physiological and pathophysiological conditions of the neurovascular unit.Neuropathology : official journal of the Japanese Society of Neuropathology · 2020Review
- Review
- Lanthanum damages learning and memory and suppresses astrocyte-neuron lactate shuttle in rat hippocampus.Experimental brain research · 2017Article
- Emerging Roles for Glycogen in the CNS.Frontiers in molecular neuroscience · 2017Review
- Monoaminergic Control of Cellular Glucose Utilization by Glycogenolysis in Neocortex and Hippocampus.Neurochemical research · 2015Review
- Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism.Nature communications · 2015Article
- Gap junctions and Bystander Effects: Good Samaritans and executioners.Wiley interdisciplinary reviews. Membrane transport and signaling · 2013Article
- The role of astrocytic glycogen in supporting the energetics of neuronal activity.Neurochemical research · 2012Review
- Sweet sixteen for ANLS.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2012Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Recognition of glycogen as an active participant in the energetics of brain activation is replacing the long-held concept of glycogen as an emergency energy reserve, but the functional roles of glycogen and the cellular utilization of glycogen carbon are unresolved issues. Metabolic modeling by DiNuzzo et al, in this issue predicts that mobilization of glycogen during brain activation provides fuel for activated astrocytes and increases product inhibition of hexokinase thereby reducing astrocytic utilization of blood-borne glucose and increasing glucose availability for activated neurons. Glucose buffering and glucose channeling (not lactate shuttling to neurons) are proposed to be the consequences of glycogenolysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.