ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2011
Baseline CBF, and BOLD, CBF, and CMRO2 fMRI of visual and vibrotactile stimulations in baboons.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 42 citations in OpenAlex.
- The Role of fMRI in Drug Development: An Update.Advances in neurobiology · 2023Article
- Altered linear coupling between stimulus-evoked blood flow and oxygen metabolism in the aging human brain.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Dynamics of the cerebral blood flow response to brief neural activity in human visual cortex.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Large animal ischemic stroke models: replicating human stroke pathophysiology.Neural regeneration research · 2020Review
- White matter and hypoxic hypobaria in humans.Human brain mapping · 2019Article
- Effects of flow changes on radiotracer binding: Simultaneous measurement of neuroreceptor binding and cerebral blood flow modulation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- The role of fMRI in drug development.Drug discovery today · 2018Review
- Reproducibility of quantitative structural and physiological MRI measurements.Brain and behavior · 2017Article
- Changes in Cerebral Blood Flow during an Alteration in Glycemic State in a Large Non-human Primate (Frontiers in neuroscience · 2017Article
- Neural-metabolic coupling in the central visual pathway.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Quantitative β mapping for calibrated fMRI.NeuroImage · 2016Article
- Resting-state functional connectivity in the baboon model of genetic generalized epilepsy.Epilepsia · 2015Article
- Cerebrovascular reactivity measured with arterial spin labeling and blood oxygen level dependent techniques.Magnetic resonance imaging · 2015Article
- Ultra-high spatial resolution basal and evoked cerebral blood flow MRI of the rat brain.Brain research · 2015Article
- Article
- Accelerated white matter aging in schizophrenia: role of white matter blood perfusion.Neurobiology of aging · 2014Article
- Hyperglycemic Challenge and Distribution of Adipose Tissue in Obese Baboons.International journal of diabetology & vascular disease research · 2014Article
- The oxygen paradox of neurovascular coupling.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Article
- A computational model of oxygen transport in the cerebrocapillary levels for normal and pathologic brain function.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Neurovascular coupling associated with visual and vibrotactile stimulations in baboons anesthetized sequentially with isoflurane and ketamine was evaluated using multimodal functional magnetic resonance imaging (fMRI) on a clinical 3-Tesla scanner. Basal cerebral blood flow (CBF), and combined blood-oxygenation-level-dependent (BOLD) and CBF fMRI of visual and somatosensory stimulations were measured using pseudo-continuous arterial spin labeling. Changes in stimulus-evoked cerebral metabolic rate of oxygen (CMRO(2)) were estimated using calibrated fMRI. Arterial transit time for vessel, gray matter (GM), and white matter (WM) were 250, 570, and 823 ms, respectively. Gray matter and WM CBF, respectively, were 107.8±7.9 and 47.8±3.8 mL per 100 g per minute under isoflurane, and 108.8±10.3 and 48.7±4.2 mL per 100 g per minute under ketamine (mean±s.e.m., N=8 sessions, five baboons). The GM/WM CBF ratio was not statistically different between the two anesthetics, averaging 2.3±0.1. Hypercapnia evoked global BOLD and CBF increases. Blood-oxygenation-level-dependent, CBF, and CMRO(2) signal changes by visual and vibrotactile stimulations were 0.19% to 0.22%, 18% to 23%, and 4.9% to 6.7%, respectively. The CBF/CMRO(2) ratio was 2.9 to 4.7. Basal CBF and fMRI responses were not statistically different between the two anesthetics. This study establishes a multimodal fMRI protocol to probe clinically relevant functional, physiological and metabolic information in large nonhuman primates.
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