Evidence map›Paper›PMID 20826830›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2010

Survival of women with colon cancer in relation to precancer anthropometric characteristics: the Iowa Women's Health Study.

Anna E Prizment, Andrew Flood, Kristin E Anderson, Aaron R Folsom

Abstract read
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In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Obesity in cancer survival.Annual review of nutrition · 2012
    Pooled it
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  11. Microsatellite Instability and Life Style Factors in Sporadic Colorectal Cancer.Asian Pacific journal of cancer prevention : APJCP · 2020
    Article
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  13. Review
  14. Article
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  16. Obesity and Energy Balance in GI Cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2016
    Review
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  18. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Anna E PrizmentDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota 55455, USA. prizm001@mail.umn.edu
Andrew Flood
Kristin E Anderson
Aaron R Folsom

Funding

EPIDEMIOLOGY OF CANCER IN A COHORT OF OLDER WOMENR01CA039742 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LAZOVICH, DEANN · 1985 to 2014
$8.0M
NCI NIH HHS R01 CA039742NCI NIH HHS R01 CA39742
6 · The paper itself

Abstract

backgroundWe hypothesized that precancer anthropometric variables are associated with mortality among women who developed colon cancer in a prospective cohort, the Iowa Women's Health Study (IWHS).

methodsFrom 1986 to 2005, 1,096 incident cases of colon cancer were identified (mean age at diagnosis, 73 years). Anthropometric characteristics were self-measured before colon cancer diagnosis (in 1986). Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI) for all-cause and colon-cancer mortality, adjusted for age at cancer diagnosis, stage, education, smoking status, and pack-years of smoking.

resultsDuring the follow-up of up to 20 years, 493 women died; 289 had colon cancer as the underlying cause. The HRs of all-cause death were increased for the highest versus lowest tertile for weight (HR, 1.39; 95% CI, 1.10-1.76; P trend = 0.005); waist to hip ratio (WHR; HR, 1.36; 95% CI, 1.08-1.72; P trend = 0.008), and waist (HR, 1.45; 95% CI, 1.15-1.82; P trend = 0.001). Compared with that for body mass index (BMI) of 18.5 to 24.9 kg/m(2), HRs were increased for BMI >or=30 kg/m(2) (HR, 1.45; 95% CI, 1.14-1.85) and for the few women with BMI <18.5 kg/m(2) (HR, 1.89; 95% CI, 1.01-3.53). Colon cancer mortality was positively associated with WHR and waist: HR, 1.37 (95% CI, 1.02;1.85; P trend = 0.04) and 1.34 (95% CI, 1.01-1.80; P trend = 0.05), respectively, for the highest versus lowest tertile.

conclusionGreater precancer anthropometric measures and BMI <18.5 kg/m(2) predicted poorer survival among colon cancer patients. Higher abdominal adiposity measured by WHR and waist was associated with increased risk of colon cancer death. IMPACT: Prediagnostic obesity may be a modifiable risk factor for death in colon cancer patients.

Indexed as

AgedAnthropometryBody Mass IndexCohort StudiesColonic NeoplasmsFemaleHumansIncidenceIowaMiddle AgedObesityProportional Hazards ModelsProspective StudiesQuality of LifeRisk FactorsSurveys and Questionnaires

Identifiers

PMID20826830
PMCPMC2945249

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.