ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2010
Carotid baroreflex control of arterial blood pressure at rest and during dynamic exercise in aging humans.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- The association of elevated blood pressure during ischaemic exercise with sport performance in Master athletes with and without morbidity.European journal of applied physiology · 2022Article
- Midlife aerobic exercise and dynamic cerebral autoregulation: associations with baroreflex sensitivity and central arterial stiffness.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Baroreceptor Modulation of the Cardiovascular System, Pain, Consciousness, and Cognition.Comprehensive Physiology · 2021Article
- Contribution of Baroreceptor Function to Pain Perception and Perioperative Outcomes.Anesthesiology · 2019Review
- Baroreflex and neurovascular responses to skeletal muscle mechanoreflex activation in humans: an exercise in integrative physiology.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Review
- Arterial baroreflex control of sympathetic nerve activity and heart rate in patients with type 2 diabetes.American journal of physiology. Heart and circulatory physiology · 2016Article
- Impaired carotid baroreflex control of arterial blood pressure in multiple sclerosis.Journal of neurophysiology · 2016Article
- Aging alters muscle reflex control of autonomic cardiovascular responses to rhythmic contractions in humans.American journal of physiology. Heart and circulatory physiology · 2015Article
- A beat-by-beat analysis of cardiovascular responses to dry resting and exercise apnoeas in elite divers.European journal of applied physiology · 2015Article
- Beneficial effects of physical activity on baroreflex control in the elderly.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2014Review
- Effect of aging on carotid baroreflex control of blood pressure and leg vascular conductance in women.American journal of physiology. Heart and circulatory physiology · 2014Article
- Spontaneous fluctuation indices of the cardiovagal baroreflex accurately measure the baroreflex sensitivity at the operating point during upright tilt.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Carotid baroreflex responsiveness in normotensive African Americans is attenuated at rest and during dynamic leg exercise.Frontiers in physiology · 2013Article
- New insights into the effects of age and sex on arterial baroreflex function at rest and during dynamic exercise in humans.Autonomic neuroscience : basic & clinical · 2012Review
- Effect of sex and ovarian hormones on carotid baroreflex resetting and function during dynamic exercise in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Hysteresis in the sympathetic baroreflex: role of baseline nerve activity.The Journal of physiology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The arterial baroreflex is fundamental for evoking and maintaining appropriate cardiovascular adjustments to exercise. We sought to investigate how aging influences carotid baroreflex regulation of blood pressure (BP) during dynamic exercise. BP and heart rate (HR) were continuously recorded at rest and during leg cycling performed at 50% HR reserve in 15 young (22 ± 1 yr) and 11 older (61 ± 2 yr) healthy subjects. Five-second pulses of neck pressure and neck suction from +40 to -80 Torr were applied to determine the full carotid baroreflex stimulus response curve and examine baroreflex resetting during exercise. Although the maximal gain of the modeled stimulus response curve was similar in both groups at rest and during exercise, in older subjects the operating point (OP) was located further away from the centering point (CP) and toward the reflex threshold, both at rest (OP minus CP; -10 ± 3 older vs. 0 ± 2 young mmHg, P < 0.05) and during exercise (OP minus CP; -10 ± 2 older vs. 1 ± 3 young mmHg, P < 0.05). In agreement, older subjects demonstrated a reduced BP response to neck pressure (simulated carotid hypotension) and a greater BP response to neck suction (simulated carotid hypertension). In addition, the magnitude of the upward and rightward resetting of the carotid baroreflex-BP stimulus response curve with exercise was ∼40% greater in older individuals. These data indicate that despite a maintained maximal gain, the ability of the carotid baroreflex to defend against a hypotensive challenge is reduced, whereas responses to hypertensive stimuli are greater with advanced age, both at rest and during exercise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.