ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
The germinal zones of the basal ganglia but not the septum generate GABAergic interneurons for the cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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50 citing papers in PubMed, 84 citations in OpenAlex.
- Hypoxia-inducible factor signaling regulates embryonic interneuron development, GRIN2B expression and adult cortical function.Developmental cell · 2026Article
- Astrocyte specification in the mouse septum is shaped by both developmental origin and local signals.Nature neuroscience · 2025Article
- A comparative view of human and mouse telencephalon inhibitory neuron development.Development (Cambridge, England) · 2025Review
- Developmental origin and local signals cooperate to determine septal astrocyte identity.bioRxiv : the preprint server for biology · 2023Article
- A developmentally defined population of neurons in the lateral septum controls responses to aversive stimuli.bioRxiv : the preprint server for biology · 2023Article
- Interneuron odyssey: molecular mechanisms of tangential migration.Frontiers in neural circuits · 2023Review
- Fate mapping reveals mixed embryonic origin and unique developmental codes of mouse forebrain septal neurons.Communications biology · 2022Article
- MTG8 interacts with LHX6 to specify cortical interneuron subtype identity.Nature communications · 2022Article
- Single cell enhancer activity distinguishes GABAergic and cholinergic lineages in embryonic mouse basal ganglia.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Cellular resolution anatomical and molecular atlases for prenatal human brains.The Journal of comparative neurology · 2022Article
- Origin, Development, and Synaptogenesis of Cortical Interneurons.Frontiers in neuroscience · 2022Review
- Interneuron origin and molecular diversity in the human fetal brain.Nature neuroscience · 2021Article
- Article
- Review
- Cortical distribution of GABAergic interneurons is determined by migration time and brain size.Development (Cambridge, England) · 2020Article
- The role of the diencephalon in the guidance of thalamocortical axons in mice.Development (Cambridge, England) · 2020Article
- Hippocampal CA1 Somatostatin Interneurons Originate in the Embryonic MGE/POA.Stem cell reports · 2019Article
- Expression of ventral telencephalon transcription factors ASCL1 and DLX2 in the early fetal human cerebral cortex.Journal of anatomy · 2019Article
- New insights into the development of the human cerebral cortex.Journal of anatomy · 2019Review
- White matter neuron biology and neuropathology in schizophrenia.NPJ schizophrenia · 2019Review
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
Cortical interneurons originate from subpallial precursors and migrate into the cortex during development. Using genetic lineage tracing in transgenic mice we examine the contribution of two germinal zones, the septum and the lateral ganglionic eminence/caudal ganglionic eminence (LGE/CGE) to interneurons of the cortex. We find that the septal neuroepithelium does not generate interneurons for the neocortex. There is, however, clear migration of cells from the LGE/CGE to the cortex. Comparison of the dynamics of cortical colonization by the two major cohorts of interneurons originating in the medial ganglionic eminence (MGE) and the LGE/CGE has shown differences in the timing of migration and initial route of entry into the cortex. LGE/CGE-derived interneurons enter the cortex later than the MGE-derived ones. They invade the cortex through the subventricular/intermediate zone route and only later disperse within the cortical plate and the marginal zone. During the first postnatal week MGE interneurons move extensively to acquire their laminar position within the cortical plate whereas LGE/CGE-derived cells remain largely within the upper layers of the cortex. The two populations intermingle in the adult cortex but have distinct neurochemical properties and different overall distributions. LGE/CGE-derived interneurons account for one third of the total GABAergic interneuron population in the adult cortex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.