ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Multivesicular release differentiates the reliability of synaptic transmission between the visual cortex and the somatosensory cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Multivesicular release favors short term synaptic depression in hippocampal autapses.Frontiers in cellular neuroscience · 2023Article
- The Impact of Multivesicular Release on the Transmission of Sensory Information by Ribbon Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Diurnal changes in the efficiency of information transmission at a sensory synapse.Nature communications · 2022Article
- Structure and function of a neocortical synapse.Nature · 2021Article
- Myosin V Regulates Spatial Localization of Different Forms of Neurotransmitter Release in Central Synapses.Frontiers in synaptic neuroscience · 2021Article
- Article
- Unveiling the Synaptic Function and Structure Using Paired Recordings From Synaptically Coupled Neurons.Frontiers in synaptic neuroscience · 2020Review
- Estimating the Readily-Releasable Vesicle Pool Size at Synaptic Connections in the Neocortex.Frontiers in synaptic neuroscience · 2019Article
- Synaptic weight set by Munc13-1 supramolecular assemblies.Nature neuroscience · 2018Article
- The ubiquitous nature of multivesicular release.Trends in neurosciences · 2015Review
- Electrophysiological and morphological characterization of neuronal microcircuits in acute brain slices using paired patch-clamp recordings.Journal of visualized experiments : JoVE · 2015Article
- Activity-dependent regulation of release probability at excitatory hippocampal synapses: a crucial role of fragile X mental retardation protein in neurotransmission.The European journal of neuroscience · 2014Article
- Activation of extrasynaptic NMDARs at individual parallel fiber-molecular layer interneuron synapses in cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Paired-pulse facilitation at recurrent Purkinje neuron synapses is independent of calbindin and parvalbumin during high-frequency activation.The Journal of physiology · 2013Article
- Selective presynaptic enhancement of the prefrontal cortex to nucleus accumbens pathway by cocaine.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Norepinephrine drives persistent activity in prefrontal cortex via synergistic α1 and α2 adrenoceptors.PloS one · 2013Article
- Short term synaptic depression imposes a frequency dependent filter on synaptic information transfer.PLoS computational biology · 2012Article
- Functional hallmarks of GABAergic synapse maturation and the diverse roles of neurotrophins.Frontiers in cellular neuroscience · 2011Article
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3 authors.
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Abstract
Neurons in layer 4 (L4) of the cortex play an important role in transferring signals from thalamus to other layers of the cortex. Understanding the fundamental properties of synaptic transmission between L4 neurons helps us gain a clear picture of how the neuronal network in L4 cooperates to process sensory information. In the present study, we have determined the underlying parameters that govern synaptic strength, such as quantal size, size of readily releasable vesicle pool, and release probability (Pr) of excitatory synaptic connections within L4 of the visual cortex (V1) and the somatosensory cortex (S1) in mice. Although only a single vesicle is released per release site under physiological conditions at V1 synapses, multivesicular release (MVR) is observed at S1 synapses. In addition, we observed a saturation of postsynaptic receptors at S1 synapses. Other synaptic properties are similar in both cortices. Dynamic clamp experiments suggest that higher Pr and MVR at S1 synapses lower the requirement of the number of synaptic inputs to generate postsynaptic action potentials. In addition, the slower decay of synaptic current and the intrinsic membrane properties of the postsynaptic neuron also contribute to the reliable transmission between S1 neurons.
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