ArticleJournal of clinical microbiology2010
Molecular evidence of cholera outbreak caused by a toxigenic Vibrio cholerae O1 El tor variant strain in Kelantan, Malaysia.
Article in Journal of clinical microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 47 citations in OpenAlex.
- The incidence, and spatial trends of cholera in Sabah over 15 years: Repeated outbreaks in coastal areas.PLOS global public health · 2024Article
- Article
- Cholera outbreak caused by drinking unprotected well water contaminated with faeces from an open storm water drainage: Kampala City, Uganda, January 2019.BMC infectious diseases · 2021Article
- Origin and Dissemination of Altered El Tor Vibrio cholerae O1 Causing Cholera in Odisha, India: Two and Half Decade's View.Frontiers in microbiology · 2021Article
- Role of coaggregation in the pathogenicity and prolonged colonisation of Vibrio cholerae.Medical microbiology and immunology · 2019Article
- Prevalence, antimicrobial susceptibility and plasmid profiling of Vibrio spp. isolated from cultured groupers in Peninsular Malaysia.BMC microbiology · 2019Article
- Comparison and Evaluation of the Molecular Typing Methods for ToxigenicFrontiers in microbiology · 2018Article
- O Serogroup-Specific Touchdown-Multiplex Polymerase Chain Reaction for Detection and Identification of Vibrio cholerae O1, O139, and Non-O1/Non-O139.Biochemistry research international · 2014Article
- Molecular characterization of the circulating strains of Vibrio cholerae during 2010 cholera outbreak in Nigeria.Journal of health, population, and nutrition · 2013Article
- Drug response and genetic properties of Vibrio cholerae associated with endemic cholera in north-eastern Thailand, 2003-2011.Journal of medical microbiology · 2013Article
- Molecular characterization of high-level-cholera-toxin-producing El Tor variant Vibrio cholerae strains in the Zanzibar Archipelago of Tanzania.Journal of clinical microbiology · 2013Article
- Cholera outbreaks in Nigeria are associated with multidrug resistant atypical El Tor and non-O1/non-O139 Vibrio cholerae.PLoS neglected tropical diseases · 2013Article
- Outbreak-associated Vibrio cholerae genotypes with identical pulsotypes, Malaysia, 2009.Emerging infectious diseases · 2012Article
- Development and evaluation of a PCR assay for tracking the emergence and dissemination of Haitian variant ctxB in Vibrio cholerae O1 strains isolated from Kolkata, India.Journal of clinical microbiology · 2012Article
- Multi-drug resistant Vibrio cholerae O1 variant El Tor isolated in northern Vietnam between 2007 and 2010.Journal of medical microbiology · 2012Article
- New V. cholerae atypical El Tor variant emerged during the 2006 epidemic outbreak in Angola.BMC microbiology · 2011Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A total of 20 Vibrio cholerae isolates were recovered for investigation from a cholera outbreak in Kelantan, Malaysia, that occurred between November and December 2009. All isolates were biochemically characterized as V. cholerae serogroup O1 Ogawa of the El Tor biotype. They were found to be resistant to multiple antibiotics, including tetracycline, erythromycin, sulfamethoxazole-trimethoprim, streptomycin, penicillin G, and polymyxin B, with 35% of the isolates being resistant to ampicillin. All isolates were sensitive to ciprofloxacin, norfloxacin, chloramphenicol, gentamicin, and kanamycin. Multiplex PCR analysis confirmed the biochemical identification and revealed the presence of virulence genes, viz., ace, zot, and ctxA, in all of the isolates. Interestingly, the sequencing of the ctxB gene showed that the outbreak strain harbored the classical cholera toxin gene and therefore belongs to the newly assigned El Tor variant biotype. Clonal analysis by pulsed-field gel electrophoresis demonstrated that a single clone of a V. cholerae strain was responsible for this outbreak. Thus, we present the first molecular evidence that the toxigenic V. cholerae O1 El Tor variant has invaded Malaysia, highlighting the need for continuous monitoring to facilitate early interventions against any potential epidemic by this biotype.
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