Evidence map›Paper›PMID 20826632›Full record

Trial reportThe Journal of nutrition2010

Lifestyle counseling and supplementation with flaxseed or walnuts influence the management of metabolic syndrome.

Hongyu Wu, An Pan, Zhijie Yu, Qibin Qi, Ling Lu, Geng Zhang, Danxia Yu, Geng Zong, Yunhua Zhou, Xiafei Chen and 8 more

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 17 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 17 syntheses or guidelines pooled it, 159 citations in OpenAlex.

  1. Effects of Walnut (Juglans regia L.) on Blood Pressure and Endothelial Function in Adults: A Systematic Review and Dose-Response Meta-Analysis.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Pooled it
  14. Pooled it
  15. Pooled it
  16. Nut consumption for the primary prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2015
    Pooled it
  17. Pooled it
  18. Trial
  19. Trial
  20. Trial

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 2 countries.

Hongyu WuKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China.
An Pan
Zhijie Yu
Qibin Qi
Ling Lu
Geng Zhang
Danxia Yu
Geng Zong
Yunhua Zhou
Xiafei Chen
Lixin Tang
Ying Feng
Hong Zhou
Xiaolei Chen
Huaixing Li
Wendy Demark-Wahnefried
Frank B Hu
Xu Lin
Chinese Academy of Sciences · CNShanghai University · CNFudan University · CNBrigham and Women's Hospital · USHarvard University · USUniversity of Alabama at Birmingham · US

Funding

Prostate Cancer: Impact of Fat &Flaxseed Modified DietR01CA085740 · NCI · DUKE UNIVERSITY · PI DEMARK-WAHNEFRIED, WENDY · 2002 to 2005
$1.2M
NCI NIH HHS R01 CA085740
6 · The paper itself

Abstract

A healthy lifestyle may ameliorate metabolic syndrome (MetS); however, it remains unclear if incorporating nuts or seeds into lifestyle counseling (LC) has additional benefit. A 3-arm, randomized, controlled trial was conducted among 283 participants screened for MetS using the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian Americans. Participants were assigned to a LC on the AHA guidelines, LC + flaxseed (30 g/d) (LCF), or LC + walnuts (30 g/d) (LCW) group. After the 12-wk intervention, the prevalence of MetS decreased significantly in all groups: -16.9% (LC), -20.2% (LCF), and -16.0% (LCW). The reversion rate of MetS, i.e. those no longer meeting the MetS criteria at 12 wk, was not significantly different among groups (LC group, 21.1%; LCF group, 26.6%; and LCW group, 25.5%). However, the reversion rate of central obesity was higher in the LCF (19.2%; P = 0.008) and LCW (16.0%; P = 0.04) groups than in the LC group (6.3%). Most of the metabolic variables (weight, waist circumference, serum glucose, total cholesterol, LDL cholesterol, apolipoprotein (Apo) B, ApoE, and blood pressure) were significantly reduced from baseline in all 3 groups. However, the severity of MetS, presented as the mean count of MetS components, was significantly reduced in the LCW group compared with the LC group among participants with confirmed MetS at baseline (P = 0.045). Our results suggest that a low-intensity lifestyle education program is effective in MetS management. Flaxseed and walnut supplementation may ameliorate central obesity. Further studies with larger sample sizes and of longer duration are needed to examine the role of these foods in the prevention and management of MetS.

Indexed as

FlaxJuglansLife StyleNutsSeedsAdultAgedBlood GlucoseBody Mass IndexBreadCombined Modality TherapyFemaleHumansLipidsMaleMetabolic SyndromeBlood GlucoseLipids

Identifiers

PMID20826632
PMCPMC3361016
OpenAlexW2128294843

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.