ArticleAmerican journal of physiology. Renal physiology2010
Connecting tubule glomerular feedback antagonizes tubuloglomerular feedback in vivo.
Article in American journal of physiology. Renal physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Epithelial N-methyl-D-aspartate (NMDA) receptors mediate renal vasodilation by affecting kidney autoregulation.bioRxiv : the preprint server for biology · 2023Article
- Decreased tubuloglomerular feedback response in high-fat diet-induced obesity.American journal of physiology. Renal physiology · 2022Article
- Sensing of tubular flow and renal electrolyte transport.Nature reviews. Nephrology · 2020Review
- Nitric oxide mediates anomalous tubuloglomerular feedback in rats fed high-NaCl diet after subtotal nephrectomy.American journal of physiology. Renal physiology · 2019Article
- Role of connecting tubule glomerular feedback in obesity related renal damage.American journal of physiology. Renal physiology · 2018Article
- ENaC blockade in proteinuria-associated extracellular fluid volume overload - effective but risky.Physiological reports · 2018Article
- Effect of salt intake on afferent arteriolar dilatation: role of connecting tubule glomerular feedback (CTGF).American journal of physiology. Renal physiology · 2017Article
- Tubuloglomerular and connecting tubuloglomerular feedback during inhibition of various Na transporters in the nephron.American journal of physiology. Renal physiology · 2015Article
- Renal autoregulation in health and disease.Physiological reviews · 2015Review
- Distal convoluted tubule.Comprehensive Physiology · 2015Review
- Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy.Journal of the American Society of Nephrology : JASN · 2014Article
- Acute inhibition of NCC does not activate distal electrogenic Na+ reabsorption or kaliuresis.American journal of physiology. Renal physiology · 2014Article
- Molecular mechanisms of renal blood flow autoregulation.Current vascular pharmacology · 2014Review
- Oxidative stress in hypertension: role of the kidney.Antioxidants & redox signaling · 2014Review
- Prostaglandin E2 mediates connecting tubule glomerular feedback.Hypertension (Dallas, Tex. : 1979) · 2013Article
- Connecting tubule glomerular feedback in hypertension.Hypertension (Dallas, Tex. : 1979) · 2013Article
- Central systolic augmentation indexes and urinary sodium in a white population.American journal of hypertension · 2013Article
- Mechanisms of angiotensin II-enhanced connecting tubule glomerular feedback.American journal of physiology. Renal physiology · 2012Article
- Connecting tubule glomerular feedback mediates acute tubuloglomerular feedback resetting.American journal of physiology. Renal physiology · 2012Article
- Luminal flow regulates NO and O2(-) along the nephron.American journal of physiology. Renal physiology · 2011Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In vitro experiments showed that the connecting tubule (CNT) sends a signal that dilates the afferent arteriole (Af-Art) when Na(+) reabsorption in the CNT lumen increases. We call this process CNT glomerular feedback (CTGF) to differentiate it from tubuloglomerular feedback (TGF), which is a cross talk between the macula densa (MD) and the Af-Art. In TGF, the MD signals the Af-Art to constrict when NaCl transport by the MD is enhanced by increased luminal NaCl. CTGF is mediated by CNT Na(+) transport via epithelial Na(+) channels (ENaC). However, we do not know whether CTGF occurs in vivo or whether it opposes the increase in Af-Art resistance caused by TGF. We hypothesized that CTGF occurs in vivo and opposes TGF. To test our hypothesis, we conducted in vivo micropuncture of individual rat nephrons, measuring stop-flow pressure (P(SF)) as an index of glomerular filtration pressure. To test whether activation of CTGF opposes TGF, we used benzamil to block CNT Na(+) transport and thus CTGF. CTGF inhibition with the ENaC blocker benzamil (1 μM) potentiated the decrease in P(SF) at 40 and 80 nl/min. Next, we tested whether we could augment CTGF by inhibiting NaCl reabsorption in the distal convoluted tubule with hydrochlorothiazide (HCTZ, 1 mM) to enhance NaCl delivery to the CNT. In the presence of HCTZ, benzamil potentiated the decrease in P(SF) at 20, 40, and 80 nl/min. We concluded that in vivo CTGF occurs and opposes the vasoconstrictor effect of TGF.
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