ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2011
Hepatic response to oxidative injury in long-lived Ames dwarf mice.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 31 citations in OpenAlex.
- Paraquat but not diquat induces TGF-β expression and thus activates calcium-NFAT axis for epithelial-mesenchymal transition.Toxicology research · 2021Article
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- GH and ageing: Pitfalls and new insights.Best practice & research. Clinical endocrinology & metabolism · 2017Review
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- Biochemical Genetic Pathways that Modulate Aging in Multiple Species.Cold Spring Harbor perspectives in medicine · 2015Review
- The somatotropic axis and longevity in mice.American journal of physiology. Endocrinology and metabolism · 2015Review
- Article
- Growth hormone alters the glutathione S-transferase and mitochondrial thioredoxin systems in long-living Ames dwarf mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- Expression of DNA methyltransferases is influenced by growth hormone in the long-living Ames dwarf mouse in vivo and in vitro.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
- Article
- Metabolic adaptations to short-term every-other-day feeding in long-living Ames dwarf mice.Experimental gerontology · 2013Article
- The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer.Critical reviews in oncology/hematology · 2013Review
- Biomarkers of oxidative stress, antioxidant defence and inflammation are altered in the senescence-accelerated mouse prone 8.Age (Dordrecht, Netherlands) · 2013Article
- Somatotropic signaling: trade-offs between growth, reproductive development, and longevity.Physiological reviews · 2013Review
- Myeloid deletion of nuclear factor erythroid 2-related factor 2 increases atherosclerosis and liver injury.Arteriosclerosis, thrombosis, and vascular biology · 2012Article
- Pyrosequencing-based transcriptomic resources in the pond snail Lymnaea stagnalis, with a focus on genes involved in molecular response to diquat-induced stress.Ecotoxicology (London, England) · 2012Article
- Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan.American journal of physiology. Endocrinology and metabolism · 2012Article
- Fibroblasts from long-lived mutant mice exhibit increased autophagy and lower TOR activity after nutrient deprivation or oxidative stress.Aging cell · 2012Article
- Insulin-like growth factor 1 physiology: lessons from mouse models.Endocrinology and metabolism clinics of North America · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
Multiple stress resistance pathways were evaluated in the liver of Ames dwarf mice before and after exposure to the oxidative toxin diquat, seeking clues to the exceptional longevity conferred by this mutation. Before diquat treatment, Ames dwarf mice, compared with nonmutant littermate controls, had 2- to 6-fold higher levels of expression of mRNAs for immediate early genes and 2- to 5-fold higher levels of mRNAs for genes dependent on the transcription factor Nrf2. Diquat led to a 2-fold increase in phosphorylation of the stress kinase ERK in control (but not Ames dwarf) mice and to a 50% increase in phosphorylation of the kinase JNK2 in Ames dwarf (but not control) mice. Diquat induction of Nrf2 protein was higher in dwarf mice than in controls. Of 6 Nrf2-responsive genes evaluated, 4 (HMOX, NQO-1, MT-1, and MT-2) remained 2- to 10-fold lower in control than in dwarf liver after diquat, and the other 2 (GCLM and TXNRD) reached levels already seen in dwarf liver at baseline. Thus, livers of Ames dwarf mice differ systematically from controls in multiple stress resistance pathways before and after exposure to diquat, suggesting mechanisms for stress resistance and extended longevity in Ames dwarf mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.