Trial reportEuropean journal of endocrinology2010
Minimal changes in environmental temperature result in a significant increase in energy expenditure and changes in the hormonal homeostasis in healthy adults.
Trial report in European journal of endocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Meta-analysis reveals glucocorticoid levels reflect variation in metabolic rate, not 'stress'.eLife · 2023Pooled it
- Interventions associated with brown adipose tissue activation and the impact on energy expenditure and weight loss: A systematic review.Frontiers in endocrinology · 2022Pooled it
- Influence of Ambient Temperature on Resting Energy Expenditure in Metabolically Healthy Males and Females.The Journal of nutrition · 2025Trial
- Trial
- Quantification of the Capacity for Cold-Induced Thermogenesis in Young Men With and Without Obesity.The Journal of clinical endocrinology and metabolism · 2019Trial
- Fasting and glucose induced thermogenesis in response to three ambient temperatures: a randomized crossover trial in the metabolic syndrome.European journal of clinical nutrition · 2018Trial
- The thermogenic responses to overfeeding and cold are differentially regulated.Obesity (Silver Spring, Md.) · 2016Trial
- Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans.Cell metabolism · 2014Trial
- Metreleptin improves blood glucose in patients with insulin receptor mutations.The Journal of clinical endocrinology and metabolism · 2013Trial
- Brown fat activation mediates cold-induced thermogenesis in adult humans in response to a mild decrease in ambient temperature.The Journal of clinical endocrinology and metabolism · 2013Trial
- Mild cold exposure modulates fibroblast growth factor 21 (FGF21) diurnal rhythm in humans: relationship between FGF21 levels, lipolysis, and cold-induced thermogenesis.The Journal of clinical endocrinology and metabolism · 2013Trial
- Pharmacokinetics and pharmacodynamics of MK-5046, a bombesin receptor subtype-3 (BRS-3) agonist, in healthy patients.Journal of clinical pharmacology · 2012Trial
- Short-Term Effects of Personal-Level Environmental Temperature on Ambulatory Blood Pressure in Patients With Hypertension: A Multicity Panel Study.Journal of the American Heart Association · 2025Article
- Serum secreted EMC10 (scEMC10) levels are inversely associated with metabolically active brown adipose tissue in humans.International journal of obesity (2005) · 2025Article
- Interplay between the brain and adipose tissue: a metabolic conversation.EMBO reports · 2024Review
- The thermoneutral zone in women takes an "arctic" shift compared to men.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Indication of mixed glucose and fatty acid use by inferred brown adipose tissue activity in Samoans.American journal of human biology : the official journal of the Human Biology Council · 2024Article
- Nipsnap1-A regulatory factor required for long-term maintenance of non-shivering thermogenesis.Molecular metabolism · 2023Article
- Interactions between central nervous system and peripheral metabolic organs.Science China. Life sciences · 2022Review
- Human total, basal and activity energy expenditures are independent of ambient environmental temperature.iScience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveResting energy expenditure (EE) is a major contributor to the total EE and thus plays an important role in body weight regulation. Adaptive thermogenesis is a major component of EE in rodents, but little is known on the effects of exposure of humans to mild and sustainable reduction in environmental temperature.
designTo characterize the dynamic changes in continuously measured resting EE, substrate utilization, and hormonal axes simultaneously in response to mild reduction in environmental temperature, we performed a cross-over intervention.
methodsTwenty-five volunteers underwent two 12-h recordings of EE in whole room indirect calorimeters at 24 and 19 °C with simultaneous measurement of spontaneous movements and hormonal axes.
resultsExposure to 19 °C resulted in an increase in plasma and urine norepinephrine levels (P<0.0001), and a 5.96% (P<0.001) increase in EE without significant changes in spontaneous physical activity. Exposure to the lower temperature resulted in a significant increase in free fatty acid levels (P<0.01), fasting insulin levels (P<0.05), and a marginal decrease in postprandial glucose levels. A small but significant (P<0.002) increase in serum free thyroxine and urinary free cortisol (P<0.05) was observed at 19 °C.
conclusionsOur observations indicate that exposure to 19 °C, a mild and tolerable cold temperature, results in a predictable increase in EE driven by a sustained rise in catecholamine and the activation of counter-regulatory mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.