ArticleNeuron2010
The clinical-basic interface in defining pathogenesis in disorders of neurodevelopmental origin.
Article in Neuron, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- The Role of the IL-33/ST2 Axis in Nervous System Development and Diseases.Immunology and cell biology · 2026Review
- Article
- Mapping Early Brain-Body Interactions: Associations of Fetal Heart Rate Variation with Newborn Brainstem, Hypothalamic, and Dorsal Anterior Cingulate Cortex Functional Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Disrupted Timing of MET Signaling Derails the Developmental Maturation of Cortical Circuits and Leads to Altered Behavior in Mice.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Editorial: Precision medicine approaches for heterogeneous conditions such as autism spectrum disorders (The need for a biomarker exploration phase in clinical trials - Phase 2m).Frontiers in psychiatry · 2022Article
- Regulation of Thyroid-disrupting Chemicals to Protect the Developing Brain.Endocrinology · 2020Review
- Using a Developmental Ecology Framework to Align Fear Neurobiology Across Species.Annual review of clinical psychology · 2019Review
- In Search of Biomarkers for Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2018Observational
- Lost in Translation: Traversing the Complex Path from Genomics to Therapeutics in Autism Spectrum Disorder.Neuron · 2018Review
- Gene regulatory mechanisms underlying sex differences in brain development and psychiatric disease.Annals of the New York Academy of Sciences · 2018Review
- Evidence for Brainstem Contributions to Autism Spectrum Disorders.Frontiers in integrative neuroscience · 2018Review
- Phenotyping, Etiological Factors, and Biomarkers: Toward Precision Medicine in Autism Spectrum Disorders.Journal of developmental and behavioral pediatrics : JDBP · 2016Article
- A developmental neuroscience approach to the search for biomarkers in autism spectrum disorder.Current opinion in neurology · 2016Review
- Prefrontal Cortex and Social Cognition in Mouse and Man.Frontiers in psychology · 2015Review
- The international society for developmental psychobiology Sackler symposium: early adversity and the maturation of emotion circuits--a cross-species analysis.Developmental psychobiology · 2014Review
- Article
- Early experiences and the development of emotional learning systems in rats.Biology of mood & anxiety disorders · 2013Review
- Serotonin homeostasis and serotonin receptors as actors of cortical construction: special attention to the 5-HT3A and 5-HT6 receptor subtypes.Frontiers in cellular neuroscience · 2013Article
- Drug development in pediatric psychiatry: current status, future trends.Child and adolescent psychiatry and mental health · 2012Article
- New frontiers in animal research of psychiatric illness.Methods in molecular biology (Clifton, N.J.) · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Human cognitive and social-emotional behaviors are heterogeneous, underscoring the challenges in modeling pathogenesis in disorders of neurodevelopmental origin in which these domains are dysfunctional. In general, animal models for these disorders are built to emulate our understanding of the clinical diagnosis, with mixed results. We suggest the utility of model systems lies in the use of different strategies to perturb hierarchical circuit development, to examine the behavioral dimensions that are most impacted, and to discern the capacity for, and heterogeneity of, neuroadaptation that will then inform treatment strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.