ArticleMedical hypotheses2011
Does transthyretin function as one of contributors for preeclampsia?
Article in Medical hypotheses, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- Transthyretin increases migration and invasion of rat placental trophoblast cells.FEBS open bio · 2020Article
- Transthyretin regulates the migration and invasion of JEG-3 cells.Oncology letters · 2017Article
- Transthyretin as a novel candidate biomarker for preeclampsia.Experimental and therapeutic medicine · 2014Article
- Human placental transthyretin in fetal growth restriction in combination with preeclampsia and the HELLP syndrome.Histochemistry and cell biology · 2012Article
- Serum Protein Profile in Women With Pregnancy Morbidity Associated With Antiphospholipid Syndrome.Journal of human reproductive sciencesArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Preeclampsia (PE) is a multi-system disorder of pregnancy, which is characterized by new onset hypertension and proteinuria, resulting in multi-organ damages within a potential procedure. However as a worldwide leading cause of maternal and fetal mortality and morbidity, the precise origin of PE has not been clarified yet, which also makes obstacles to the management of the disease. Transthyretin (TTR) is a special protein involved in amyloid diseases, has important effects on amyloid fibrils formation. We assumed that TTR might cause a disorder of maternal vascular function and contributed to the pathology of the disease by deposition of TTR amyloid fibrils in the vascular system, which are produced by variant TTR proteins, resulting in organ ischemia. If this hypothesis proves to be correct, this variant may be of diagnostic importance as novel biomarkers for the disease, in addition, it might also benefit to the management of PE.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.