ArticleCritical care (London, England)2010
Clinical correlates of arterial lactate levels in patients with ST-segment elevation myocardial infarction at admission: a descriptive study.
Article in Critical care (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 89 citations in OpenAlex.
- Half-molar sodium lactate infusion improves cardiac performance in acute heart failure: a pilot randomised controlled clinical trial.Critical care (London, England) · 2014Trial
- Lactylation at the metabolic-epigenetic interface in cardiovascular diseases: context-dependent mechanisms and translational roadmap.Journal of advanced research · 2026Review
- Correlation analysis of arterial blood lactate levels with major in-hospital adverse cardiovascular events after coronary intervention in patients with acute myocardial infarction.BMC research notes · 2026Article
- Lactate and lactylation: mechanisms, function, diseases, and therapeutic targets.Molecular biomedicine · 2026Review
- From Byproduct to Regulator: The Expanding Role of Lactate and Lactylation in Cardiovascular Physiology and Disease.Biology · 2026Review
- Serial Lactate in Clinical Medicine - A Narrative Review.Journal of intensive care medicine · 2026Review
- Acidemia predicts mortality independently of lactate levels in patients after cardiac arrest.Resuscitation plus · 2026Article
- Lactate: elucidating its indispensable role in human health.Molecular cancer · 2026Review
- Acute alterations in blood lactate in the setting of transient stress induced myocardial ischaemia.Experimental physiology · 2026Article
- The detection of cardiovascular biomarkers in dermal interstitial fluid - a step to real-time monitoring.Frontiers in cardiovascular medicine · 2026Review
- Correlation Between Early Arterial Lactate Levels, Arterial Bicarbonate Ion Levels, and the Lactate/Albumin Ratio and In-Hospital Mortality in Patients With Acute Myocardial Infarction Complicated With Cardiac Shock.Cardiology research and practice · 2026Article
- Myocardial Inflammation as Key Mediator of Heart-brain Interaction After Myocardial Ischemia/Infarction: Mechanistic Exploration of Post-Myocardial Infarction Cognitive Dysfunction.Current neuropharmacology · 2026Review
- Lactate Metabolism and Lactylation Modification: New Opportunities and Challenges in Cardiovascular Disease.MedComm · 2025Review
- Lactate orchestrates metabolic hemodynamic adaptations through a unique combination of venocontraction, artery relaxation, and positive inotropy.Acta physiologica (Oxford, England) · 2025Article
- CNDP2: An Enzyme Linking Metabolism and Cardiovascular Diseases?Journal of cardiovascular translational research · 2025Review
- Prognostic value of serum lactate level for mortality in patients with acute kidney injury.European journal of medical research · 2024Article
- The role of stress hyperglycemia and hyperlactatemia in non-diabetic patients with myocardial infarction treated with percutaneous coronary intervention.Cardiology journal · 2024Observational
- Association of Lactate with Risk of Cardiovascular Diseases: A Two-Sample Mendelian Randomization Study.Vascular health and risk management · 2024Article
- The role of lactate in cardiovascular diseases.Cell communication and signaling : CCS · 2023Review
- Association between lactate/albumin ratio and all-cause mortality in critical patients with acute myocardial infarction.Scientific reports · 2023Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionBlood lactate measurements can be used as an indicator of hemodynamic impairment and relate to mortality in various forms of shock. Little is known at the moment concerning the clinical correlates of systemic lactate in patients with ST-segment elevation myocardial infarction (STEMI).
methodsTo assess the relation of systemic arterial lactate levels in STEMI patients with clinical correlates at presentation in the catheterization laboratory, we measured arterial lactate levels with a rapid point-of-care technique, immediately following femoral sheath insertion. The study population (n = 1,176) was divided into tertiles with lactate levels ≤ 1.1 (n = 410), 1.2 to 1.7 (n = 398) and ≥ 1.8 mmol/l (n = 368). We compared both baseline characteristics and outcome measures of the three lactate groups.
resultsFactors independently associated with higher lactate levels were hypotension, heart rate, thrombolysis in myocardial infarction (TIMI) flow 0 to 1, diabetes and non-smoking. Mortality at 30 days in the three groups was 2.0%, 1.5% and 6.5%. The latter group also showed lower blush grades and greater enzymatic infarct sizes. An intra aortic balloon pump (IABP) was used more frequently in patients with higher lactate levels (4.2%, 7.6% and 14.7%).
conclusionsIn STEMI patients, impaired hemodynamics, worse TIMI flow and non-smoking were related to increased arterial lactate levels. Higher lactate levels were independently related with 30-day mortality and an overall worse response to percutaneous coronary intervention (PCI). In particular, acute mortality was related to admission lactates ≥ 1.8 mmol/L. Point-of-care measurement of arterial lactate at admission in patients with STEMI has the potential to improve acute risk stratification.
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