ArticleBiology direct2010
Asymmetric and non-uniform evolution of recently duplicated human genes.
Article in Biology direct, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Quantifying the Influence of Genetic Context on Duplicated Mammalian Genes.Molecular biology and evolution · 2026Article
- Unveiling the functional fate of duplicated genes through expression profiling and structural analysis.Genome research · 2025Article
- Quantifying the influence of genetic context on duplicated mammalian genes.bioRxiv : the preprint server for biology · 2025Article
- Gene duplication and rate variation in the evolution of plastid ACCase and Clp genes in angiosperms.Molecular phylogenetics and evolution · 2022Article
- Nramp: Deprive and conquer?Frontiers in cell and developmental biology · 2022Article
- Special Care Is Needed in Applying Phylogenetic Comparative Methods to Gene Trees with Speciation and Duplication Nodes.Molecular biology and evolution · 2021Article
- Recurrent sequence evolution after independent gene duplication.BMC evolutionary biology · 2020Article
- Article
- Position Matters: Network Centrality Considerably Impacts Rates of Protein Evolution in the Human Protein-Protein Interaction Network.Genome biology and evolution · 2017Article
- Article
- Protein subcellular relocalization of duplicated genes in Arabidopsis.Genome biology and evolution · 2014Article
- Long-term asymmetrical acceleration of protein evolution after gene duplication.Genome biology and evolution · 2014Article
- To the beat of a different drum: determinants implicated in the asymmetric sequence divergence of Caenorhabditis elegans paralogs.BMC evolutionary biology · 2013Article
- The PRoteomics IDEntifications (PRIDE) database and associated tools: status in 2013.Nucleic acids research · 2013Article
- Local synteny and codon usage contribute to asymmetric sequence divergence of Saccharomyces cerevisiae gene duplicates.BMC evolutionary biology · 2011Article
- A comprehensive characterization of the caspase gene family in insects from the order Lepidoptera.BMC genomics · 2011Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGene duplications are a source of new genes and protein functions. The innovative role of duplication events makes families of paralogous genes an interesting target for studies in evolutionary biology. Here we study global trends in the evolution of human genes that resulted from recent duplications.
resultsThe pressure of negative selection is weaker during a short time immediately after a duplication event. Roughly one fifth of genes in paralogous gene families are evolving asymmetrically: one of the proteins encoded by two closest paralogs accumulates amino acid substitutions significantly faster than its partner. This asymmetry cannot be explained by differences in gene expression levels. In asymmetric gene pairs the number of deleterious mutations is increased in one copy, while decreased in the other copy as compared to genes constituting non-asymmetrically evolving pairs. The asymmetry in the rate of synonymous substitutions is much weaker and not significant.
conclusionsThe increase of negative selection pressure over time after a duplication event seems to be a major trend in the evolution of human paralogous gene families. The observed asymmetry in the evolution of paralogous genes shows that in many cases one of two gene copies remains practically unchanged, while the other accumulates functional mutations. This supports the hypothesis that slowly evolving gene copies preserve their original functions, while fast evolving copies obtain new specificities or functions.
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